SARS-CoV-2 antibody vaccine response in Inflammatory Bowel Disease patients with positive anti-nucleocapsid serology or history of COVID-19 infection.

IF 1.3 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY Acta gastro-enterologica Belgica Pub Date : 2024-04-01 DOI:10.51821/87.2.12805

A Hoyois, C Gulkilik, L Mekkaoui, H Dahma, V Wambacq, C Minsart, N Rosewick, C Liefferinckx, L Amininejad, A Van Gossum, A Cremer, O Vandenberg, D Franchimont

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Abstract

Background: Previous history of COVID-19 infection is a natural booster of the vaccine response in the general population. The response to COVID-19 vaccines is lessened in Inflammatory Bowel Disease patients on selected class of immunosuppressive treatments.

Aims: The study was to assess anti-SARS-CoV-2 spike-specific IgG antibody response in Inflammatory Bowel Disease patients with a history of COVID-19 infection.

Patients and methods: This single-center prospective study involved 504 Inflammatory Bowel Disease patients. Demographic data and clinical data were gathered through questionnaires and patient charts. Anti-SARS-CoV-2 spike-specific and antinucleocapsid antibody levels were measured at T1, T2 (after the 2-dose series), and T3 or T4 (booster vaccine).

Results: This study included 504 Inflammatory Bowel Disease patients, and 234 completed one year follow-up with blood tests. Positive anti-nucleocapsid serology or history of COVID-19 infection was significantly associated with increased median anti- SARS-CoV-2 spike-specific IgG titers after the 2-dose series (1930 BAU/mL vs. 521 BAU/mL p < 0.0001) and the booster vaccine (4390 BAU/mL vs. 2160 BAU/mL, p = 0.0156). Multivariate analysis showed that higher anti-SARS-CoV-2 spike-specific IgG levels were independently associated with anti-nucleocapsid antibodies at T2 (OR=2.23, p < 0.0001) and T3 (OR=1.72, p = 0.00011). Immunosuppressive treatments did not impact the antibody response or levels in patients with a history of COVID-19 infection or positive anti-nucleocapsid serology.

Conclusions: In Inflammatory Bowel Disease, prior COVID-19 infection or positive anti-nucleocapsid serology leads to increased anti-SARS-CoV-2 spike-specific IgG levels after vaccination, regardless of immunosuppressive treatments. This emphasizes the significance of accounting for previous infection in vaccination approaches.

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抗核苷酸血清学阳性或有 COVID-19 感染史的炎症性肠病患者的 SARS-CoV-2 抗体疫苗反应。

背景：在普通人群中，既往的 COVID-19 感染史会自然增强疫苗反应。目的：该研究旨在评估有 COVID-19 感染史的炎症性肠病患者的抗 SARS-CoV-2 棘突特异性 IgG 抗体反应：这项单中心前瞻性研究涉及 504 名炎症性肠病患者。通过问卷调查和病历收集了人口统计学数据和临床数据。在T1、T2（2剂系列疫苗接种后）、T3或T4（加强疫苗接种后）测定抗SARS-CoV-2尖峰特异性抗体和抗核苷酸抗体水平：这项研究包括 504 名炎性肠病患者，其中 234 人完成了为期一年的血液检测随访。抗核头状病毒血清学阳性或 COVID-19 感染史与两剂系列疫苗（1930 BAU/mL 对 521 BAU/mL，p < 0.0001）和加强疫苗（4390 BAU/mL 对 2160 BAU/mL，p = 0.0156）后抗 SARS-CoV-2 穗特异性 IgG 滴度中位数升高有显著相关性。多变量分析显示，较高的抗SARS-CoV-2尖峰特异性IgG水平与T2（OR=2.23，p < 0.0001）和T3（OR=1.72，p = 0.00011）的抗核头抗体独立相关。免疫抑制治疗不会影响有COVID-19感染史或抗核苷酸血清学阳性患者的抗体反应或水平：结论：在炎症性肠病患者中，无论免疫抑制治疗与否，接种疫苗后，COVID-19感染史或抗核苷酸血清学阳性会导致抗SARS-CoV-2尖峰特异性IgG水平升高。这强调了在疫苗接种方法中考虑既往感染的重要性。

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来源期刊

Acta gastro-enterologica Belgica Medicine-Gastroenterology

CiteScore

2.30

自引率

20.00%

发文量

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.