Postsurgical motor function and processing speed as predictors of quality of life in patients with chronic-phase glioblastoma

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-08-31 DOI:10.1007/s00701-024-06245-1

Riho Nakajima, Masashi Kinoshita, Hirokazu Okita, Mitsutoshi Nakada

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Abstract

Purpose

Patients with glioblastomas (GBMs) have poor prognosis despite various treatments; therefore, attention should be paid to maintaining the quality of survival. Neurocognitive deficits can affect the quality of life (QOL) in patients with GBM. Most studies concerning QOL and neurocognitive functions have demonstrated a relationship between QOL and self-reported neurocognitive decline, although this method does not accurately reflect damaged functional domains. Therefore, this study aimed to clarify the neurocognitive functions that influence the QOL in patients with GBMs using an objective assessment of neurocognitive functions.

Methods

Data from 40 patients newly diagnosed with GBMs were analyzed. All patients completed the assessment of QOL and various neurological and neurocognitive functions including general cognitive function, processing speed, attention, memory, emotion recognition, social cognition, visuospatial cognition, verbal fluency, language, motor function, sensation, and visual field at 6 months postoperatively. QOL was assessed using the 36-Item Short Form Survey (SF-36). In the SF-36, the physical, mental, and role and social component summary (PCS, MCS, and RCS, respectively) scores were calculated. Multiple logistic regression analyses and chi-square tests were used to evaluate the association between SF-36 scores and neurocognitive functions.

Results

The MCS was maintained, while the PCS and RCS scores were significantly lower in patients with GBMs than in healthy controls (p = 0.0040 and p < 0.0001, respectively). Among several neurocognitive functions, motor function and processing speed were significantly correlated with PCS and RCS scores, respectively (p = 0.0048 and p = 0.030, respectively). Patients who maintained their RCS or PCS scores had a higher probability of preserving motor function or processing speed than those with low RCS or PCS scores (p = 0.0026).

Conclusions

Motor function and processing speed may be predictors of QOL in patients with GBMs.

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预测慢性期胶质母细胞瘤患者生活质量的手术后运动功能和处理速度。

目的：尽管采用了多种治疗方法，但胶质母细胞瘤（GBM）患者的预后较差；因此，应注意维持患者的生存质量。神经认知功能障碍会影响 GBM 患者的生活质量（QOL）。大多数有关 QOL 和神经认知功能的研究都表明，QOL 与自我报告的神经认知功能衰退之间存在关系，尽管这种方法并不能准确反映受损的功能领域。因此，本研究旨在通过对神经认知功能的客观评估，明确影响 GBM 患者 QOL 的神经认知功能：方法：分析了 40 名新诊断为 GBMs 患者的数据。所有患者均在术后 6 个月完成了 QOL 以及各种神经和神经认知功能的评估，包括一般认知功能、处理速度、注意力、记忆力、情绪识别、社会认知、视觉空间认知、语言流畅性、语言、运动功能、感觉和视野。QOL 采用 36 项简表调查（SF-36）进行评估。在 SF-36 中，分别计算了身体、精神、角色和社交部分的总分（PCS、MCS 和 RCS）。多重逻辑回归分析和卡方检验用于评估 SF-36 评分与神经认知功能之间的关联：结果：GBMs 患者的 MCS 保持不变，而 PCS 和 RCS 分数则明显低于健康对照组（p = 0.0040 和 p 结论：GBMs 患者的运动功能和处理速度可预测其神经认知功能：运动功能和处理速度可能是预测 GBM 患者 QOL 的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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