Parathyroid Hormone Related Protein Mediated Hypercalcaemia Due to Metastatic Squamous Cell Carcinoma Originating from Pilonidal Disease: A Case Report.

IF 1 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL British journal of hospital medicine Pub Date : 2024-08-30 Epub Date: 2024-08-07 DOI:10.12968/hmed.2024.0171
Annalisa Montebello, Martina Grech, Nicoletta Maniscalco, David Pisani
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Abstract

A 56-year-old male presented with a longstanding, gradually enlarging, painful, skin lesion over the natal cleft. This was initially thought to be a pilonidal abscess but, following multiple surgeries, he was diagnosed with Stage IVb squamous cell carcinoma of the natal cleft skin with bilateral inguinal lymph node metastases and subcutaneous metastatic deposits. Complete surgical cure was not possible. He underwent radiotherapy, cisplatin chemotherapy and cemiplimab immunotherapy to control his disease. His course was complicated by severe humoral hypercalcaemia of malignancy (HHM) resistant to medical therapy. His disease progressed, and he developed widespread metastases. He was thus transferred to palliative care with pain control being the major priority. He died within a year of diagnosis.

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甲状旁腺激素相关蛋白介导的高钙血症,源于脐带疾病的转移性鳞状细胞癌:病例报告。
一名 56 岁的男性患者因产裂处皮肤病变长期存在、逐渐扩大、疼痛难忍而就诊。起初以为是皮样脓肿,但经过多次手术后,他被确诊为产裂皮肤鳞状细胞癌 IVb 期,伴有双侧腹股沟淋巴结转移和皮下转移沉积。手术无法完全治愈。为了控制病情,他接受了放疗、顺铂化疗和 cemiplimab 免疫疗法。严重的恶性体液性高钙血症(HHM)使他的病程变得复杂,对药物治疗产生了抗药性。他的病情不断恶化,并出现广泛转移。因此,他被转入姑息治疗,疼痛控制是首要任务。他在确诊后一年内去世。
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来源期刊
British journal of hospital medicine
British journal of hospital medicine 医学-医学:内科
CiteScore
1.50
自引率
0.00%
发文量
176
审稿时长
4-8 weeks
期刊介绍: British Journal of Hospital Medicine was established in 1966, and is still true to its origins: a monthly, peer-reviewed, multidisciplinary review journal for hospital doctors and doctors in training. The journal publishes an authoritative mix of clinical reviews, education and training updates, quality improvement projects and case reports, and book reviews from recognized leaders in the profession. The Core Training for Doctors section provides clinical information in an easily accessible format for doctors in training. British Journal of Hospital Medicine is an invaluable resource for hospital doctors at all stages of their career. The journal is indexed on Medline, CINAHL, the Sociedad Iberoamericana de Información Científica and Scopus.
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