Association of Serum Calcium with Carotid Atherosclerosis: A Meta-Analysis.

IF 2.2 3区医学 Q3 CLINICAL NEUROLOGY Cerebrovascular Diseases Pub Date : 2024-08-31 DOI:10.1159/000541132

Huan Li, Ruicai Xu, Yizhi Liu, Yanli Dong, Dongyue He, Xiaohui Liu, Qinjian Sun, Xuena Liu

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Abstract

Introduction: Current studies on the association between serum calcium levels and carotid atherosclerosis have yielded inconsistent results. This study aimed to elucidate this relationship through a comprehensive meta-analysis.

Methods: A systematic search of PubMed, Embase, Cochrane Library, Scopus, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Weipu (VIP), and Wanfang databases was conducted, supplemented by manual retrieval, from their inception to October 2023. Two independent researchers conducted literature searches, data extraction, and quality assessment. Meta-analysis was performed using Review Manager 5.3 software on studies that met the inclusion criteria.

Results: The analysis included 9 cross-sectional studies, encompassing a total sample size of 9,720 participants. The meta-analysis revealed a significant statistical difference in serum calcium levels between the carotid atherosclerosis group and the control group (p = 0.03). The standardized mean difference between the two groups was 0.21 (95% CI: 0.02, 0.41) using the control group as a reference.

Conclusions: Our systematic analysis indicates a significant positive correlation between serum calcium levels and carotid atherosclerosis.

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血清钙与颈动脉粥样硬化的关系：一项荟萃分析。

介绍：目前关于血清钙水平与颈动脉粥样硬化之间关系的研究结果并不一致。本研究旨在通过全面的荟萃分析来阐明这一关系：方法：对PubMed、Embase、Cochrane图书馆、Scopus、Web of Science、中国国家知识基础设施（CNKI）、中国生物医学文献数据库（CBM）、维普（VIP）和万方数据库进行了系统检索，并辅以人工检索。两名独立研究人员进行了文献检索、数据提取和质量评估。使用Review Manager 5.3软件对符合纳入标准的研究进行了元分析：分析包括 9 项横断面研究，总样本量为 9720 人。荟萃分析显示，颈动脉粥样硬化组与对照组的血清钙水平存在显著的统计学差异（P = 0.03）。以对照组为参照，两组之间的标准化平均差异为 0.21（95% CI：0.02,0.41）：我们的系统分析表明，血清钙水平与颈动脉粥样硬化之间存在明显的正相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.