Exploring the immunometabolic potential of Danggui Buxue Decoction for the treatment of IBD-related colorectal cancer.

IF 5.3 3区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE Chinese Medicine Pub Date : 2024-08-29 DOI:10.1186/s13020-024-00978-y
Yang Zhang, Qianming Kang, Luying He, Ka Iong Chan, Hui Gu, Wenjing Xue, Zhangfeng Zhong, Wen Tan
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Abstract

Danggui Buxue (DGBX) decoction is a classical prescription composed of Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), used to enrich blood, and nourish Qi in Chinese medicine, with the potential to recover energy and stimulate metabolism. Chronic inflammation is a risk factor in the development of inflammatory bowel disease (IBD)-related colorectal cancer (CRC). More importantly, AR and ASR have anti-inflammatory and anti-cancer activities, as well as prefiguring a potential effect on inflammation-cancer transformation. We, therefore, aimed to review the immunometabolism potential of DGBX decoction and its components in this malignant transformation, to provide a helpful complement to manage the risk of IBD-CRC. The present study investigates the multifaceted roles of DGBX decoction and its entire components AR and ASR, including anti-inflammation effects, anti-cancer properties, immune regulation, and metabolic regulation. This assessment is informed by a synthesis of scholarly literature, with more than two hundred articles retrieved from PubMed, Web of Science, and Scopus databases within the past two decades. The search strategy employed utilized keywords such as "Danggui Buxue", "Astragali Radix", "Angelicae Sinensis Radix", "Inflammation", and "Metabolism", alongside the related synonyms, with a particular emphasis on high-quality research and studies yielding significant findings. The potential of DGBX decoction in modulating immunometabolism holds promise for the treatment of IBD-related CRC. It is particularly relevant given the heterogeneity of CRC and the growing trend towards personalized medicine, but the precise and detailed mechanism necessitate further in vivo validation and extensive clinical studies to substantiate the immunometabolic modulation and delineate the pathways involved.

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探索当归附子汤治疗 IBD 相关结直肠癌的免疫代谢潜力
当归布血汤是由黄芪和当归组成的经典处方,在中医中用于补血益气,具有恢复体力和促进新陈代谢的作用。慢性炎症是导致与炎症性肠病(IBD)相关的结直肠癌(CRC)的危险因素。更重要的是,AR 和 ASR 具有抗炎和抗癌活性,并预示着对炎症-癌症转化的潜在影响。因此,我们旨在研究 DGBX 煎剂及其成分在这种恶性转化中的免疫代谢潜力,从而为控制 IBD-CRC 风险提供有益的补充。本研究探讨了 DGBX 煎剂及其全部成分 AR 和 ASR 的多方面作用,包括抗炎作用、抗癌特性、免疫调节和代谢调节。本评估参考了学术文献综述,从 PubMed、Web of Science 和 Scopus 数据库中检索了过去二十年中的两百多篇文章。所采用的搜索策略利用了 "当归"、"黄芪"、"当归"、"炎症 "和 "代谢 "等关键词以及相关同义词,重点关注高质量的研究和有重大发现的研究。DGBX 水煎剂在调节免疫代谢方面的潜力为治疗 IBD 相关的 CRC 带来了希望。鉴于 CRC 的异质性和日益增长的个性化医疗趋势,这一点尤为重要,但精确而详细的机制还需要进一步的体内验证和广泛的临床研究,以证实免疫代谢调节作用并确定相关途径。
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来源期刊
Chinese Medicine
Chinese Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY
CiteScore
7.90
自引率
4.10%
发文量
133
审稿时长
31 weeks
期刊介绍: Chinese Medicine is an open access, online journal publishing evidence-based, scientifically justified, and ethical research into all aspects of Chinese medicine. Areas of interest include recent advances in herbal medicine, clinical nutrition, clinical diagnosis, acupuncture, pharmaceutics, biomedical sciences, epidemiology, education, informatics, sociology, and psychology that are relevant and significant to Chinese medicine. Examples of research approaches include biomedical experimentation, high-throughput technology, clinical trials, systematic reviews, meta-analysis, sampled surveys, simulation, data curation, statistics, omics, translational medicine, and integrative methodologies. Chinese Medicine is a credible channel to communicate unbiased scientific data, information, and knowledge in Chinese medicine among researchers, clinicians, academics, and students in Chinese medicine and other scientific disciplines of medicine.
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