Serum progesterone, glycosylated hemoglobin and insulin levels with the risk of premature rupture of membranes in gestational diabetes mellitus.

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Clinics Pub Date : 2024-08-30 eCollection Date: 2024-01-01 DOI:10.1016/j.clinsp.2024.100461

LiRong Zhou, XueSong Xiong, LianHua Chen

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Abstract

Objective: To discuss the correlation between serum progesterone, glycosylated Hemoglobin (HbA1c), and insulin levels in pregnant women with Gestational Diabetes Mellitus (GDM) and the risk of Premature Rupture of Membranes (PROM).

Methods: A retrospective analysis was conducted on 52 patients diagnosed with GDM who also presented with PROM (Observation group) and compared with 89 patients diagnosed with GDM but not complicated with PROM (Control group). Progesterone, insulin, and HbA1c were detected. Risk factors for PROM in GDM patients were analyzed.

Results: The observation group had higher HbA1c and fasting blood glucose levels. Poor blood glucose control and GWG are risk factors for PROM in GDM patients. PROM increases adverse pregnancy outcomes in GDM. HbA1c, insulin, and HOMA-IR can predict the risk of PROM in GDM.

Conclusions: The effective prediction of preterm PROM can be achieved through the monitoring of serum HbA1c, insulin levels, and insulin resistance in patients with GDM.

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妊娠糖尿病患者血清孕酮、糖化血红蛋白和胰岛素水平与胎膜早破风险的关系。

目的探讨妊娠期糖尿病（GDM）孕妇的血清孕酮、糖化血红蛋白（HbA1c）和胰岛素水平与胎膜早破（PROM）风险之间的相关性：我们对 52 名确诊为 GDM 且同时伴有 PROM 的患者（观察组）进行了回顾性分析，并与 89 名确诊为 GDM 但未并发 PROM 的患者（对照组）进行了比较。对孕酮、胰岛素和 HbA1c 进行了检测。分析了GDM患者发生PROM的风险因素：观察组的 HbA1c 和空腹血糖水平较高。血糖控制不佳和 GWG 是 GDM 患者发生 PROM 的风险因素。PROM会增加GDM患者的不良妊娠结局。HbA1c、胰岛素和HOMA-IR可预测GDM患者的早产风险：结论：通过监测 GDM 患者的血清 HbA1c、胰岛素水平和胰岛素抵抗，可以有效预测早产 PROM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.