Comparative Evaluation of Periodontal Ligament-associated Protein-1/Asporin Levels in Periodontal Tissue in Health and Disease.

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE Contemporary Clinical Dentistry Pub Date : 2024-04-01 Epub Date: 2024-07-10 DOI:10.4103/ccd.ccd_114_23

Madhu Priya Manohar, R Saravana Kumar, Pratebha Balu

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Abstract

Background: Periodontal ligament-associated protein-1 (PLAP-1)/asporin is an extracellular matrix protein that plays a protective role in the pathogenesis of periodontitis. There is a paucity of information about the association between PLAP-1/asporin and periodontitis in human PDL. Thus, in this study, PLAP-1/asporin levels between participants with healthy periodontium and chronic periodontitis were compared and correlated with periodontal parameters.

Materials and methods: Fifty participants were recruited and divided into 25 in each group: Group 1 (control) and Group 2 (test). Probing pocket depth (PPD) and clinical attachment level (CAL) were recorded. Periodontal ligament (PDL) samples were collected from extracted teeth for estimating PLAP-1/asporin levels using the Human Asporin Enzyme-Linked Immunoassay Kit.

Results: A statistically significant difference (P = 0.001) in the PLAP-1/asporin levels was observed between Group 1 and Group 2. A weak negative correlation was observed between PLAP-1/asporin levels and periodontal parameters (PPD and CAL) in both groups.

Conclusion: In this study, higher PLAP-1/asporin levels in participants with healthy periodontium highlight the protective role of PLAP-1/asporin in maintaining periodontal homeostasis.

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健康和疾病牙周组织中牙周韧带相关蛋白-1/孢子蛋白水平的比较评估

背景：牙周韧带相关蛋白-1（PLAP-1）/asporin是一种细胞外基质蛋白，在牙周炎的发病机制中起保护作用。关于 PLAP-1/asporin 与人类牙周韧带中牙周炎的关系的信息还很少。因此，本研究比较了健康牙周和慢性牙周炎参与者的 PLAP-1/asporin 水平，并将其与牙周参数相关联：招募 50 名参与者，每组 25 人：第一组（对照组）和第二组（测试组）。记录探诊袋深度（PPD）和临床附着水平（CAL）。从拔出的牙齿中采集牙周韧带（PDL）样本，使用人类阿斯匹林酶联免疫测定试剂盒估算 PLAP-1/asporin 水平：第 1 组和第 2 组的 PLAP-1/asporin 水平差异有统计学意义（P = 0.001）。两组的 PLAP-1/asporin 水平与牙周参数（PPD 和 CAL）之间呈弱负相关：结论：在本研究中，牙周健康者的 PLAP-1/asporin 水平较高，这凸显了 PLAP-1/asporin 在维持牙周平衡方面的保护作用。

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来源期刊

Contemporary Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

23 weeks

期刊介绍： The journal Contemporary Clinical Dentistry (CCD) (Print ISSN: 0976-237X, E-ISSN:0976- 2361) is peer-reviewed journal published on behalf of Maharishi Markandeshwar University and issues are published quarterly in the last week of March, June, September and December. The Journal publishes Original research papers, clinical studies, case series strictly of clinical interest. Manuscripts are invited from all specialties of Dentistry i.e. Conservative dentistry and Endodontics, Dentofacial orthopedics and Orthodontics, Oral medicine and Radiology, Oral pathology, Oral surgery, Orodental diseases, Pediatric Dentistry, Periodontics, Clinical aspects of Public Health dentistry and Prosthodontics. Review articles are not accepted. Review, if published, will only be by invitation from eminent scholars and academicians of National and International repute in the field of Medical/Dental education.