Retinal Toxicity Assessment Following Vitreoretinal Surgery: A Comparison of Silicone Oil and Perfluoropropane Tamponade Using Diopsys^® NOVA^™.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY Current Eye Research Pub Date : 2024-08-30 DOI:10.1080/02713683.2024.2394118

Sadık Altan Ozal, Murat Karapapak, Ece Ozal, Serhat Ermis, Serkan Guler, Hakan Baybora, Serife Ciloglu Hayat, Yusuf Cem Yılmaz

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Abstract

Purpose: This study aimed to assess and compare the retinal toxicity associated with silicone oil (SO) and perfluoropropane (C3F8) tamponade following vitreoretinal surgery for fresh rhegmatogenous retinal detachment (RRD), utilizing the office-based Diopsys^® NOVA^™ system for evaluation.

Methods: Patients who underwent vitreoretinal surgery for fresh RRD and had SO (group 1) or C3F8 (group 2) tamponade were included in a prospective analysis. Flicker full field electroretinography (ffERG) and pattern electroretinography (PERG) tests were performed at 6 months postoperatively.

Results: Postoperative best corrected visual acuity (logMAR) was significantly different in group 1 and group 2 patients, 0.48 ± 0.3 and 0.30 ± 0.2, respectively. No significant disparities were found in demographic variables. Flicker ffERG and PERG recordings revealed notable alterations in retinal function parameters in the group 1 compared to the group 2.

Conclusion: Our findings suggest a correlation between SO tamponade and retinal dysfunction, evidenced by office-based ERG measurements. The Diopsys^® NOVA^™ protocol offers clinical ease in assessing retinal function. Further controlled studies are essential to validate these findings and guide clinical practice effectively.

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玻璃体视网膜手术后视网膜毒性评估：使用 Diopsys® NOVA™ 对硅油和全氟丙烷填塞法进行比较。

目的：本研究旨在评估和比较新鲜流变性视网膜脱离（RRD）玻璃体视网膜手术后与硅油（SO）和全氟丙烷（C3F8）填塞相关的视网膜毒性，采用基于诊室的 Diopsys® NOVA™ 系统进行评估：方法：前瞻性分析纳入了因新鲜RRD而接受玻璃体视网膜手术且有SO（第1组）或C3F8（第2组）填塞的患者。术后6个月进行闪烁全场视网膜电图（ffERG）和模式视网膜电图（PERG）测试：结果：第一组和第二组患者的术后最佳矫正视力（logMAR）有显著差异，分别为 0.48 ± 0.3 和 0.30 ± 0.2。人口统计学变量无明显差异。闪烁 ffERG 和 PERG 记录显示，与第 2 组相比，第 1 组患者的视网膜功能参数发生了明显变化：我们的研究结果表明，SO 填塞与视网膜功能障碍之间存在相关性，办公室ERG 测量结果就是证明。Diopsys® NOVA™ 方案为临床评估视网膜功能提供了便利。进一步的对照研究对验证这些发现和有效指导临床实践至关重要。

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.