Real-world evidence of allergen immunotherapy.

IF 3 4区 医学 Q2 ALLERGY Current Opinion in Allergy and Clinical Immunology Pub Date : 2024-12-01 Epub Date: 2024-08-29 DOI:10.1097/ACI.0000000000001026
Federica Buta, Giovanni Paoletti, Maria Chiara Bragato, Mattia Giovannini, Giorgio Walter Canonica, Enrico Heffler
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Abstract

Purpose of review: The full understanding of the long-term effectiveness and safety of allergen immunotherapy (AIT) for allergic respiratory diseases cannot be achieved through randomized controlled trials (RCTs) alone. However, real-world studies designed as registries can complement RCTs.

Recent findings: The significance of registries is highlighted by their potential to reassess contraindications and collect data on adult and pediatric patients with multiple comorbidities who are often excluded from RCTs.

Summary: AIT is the sole disease-modifying therapeutic approach capable of inducing tolerance and offering a long-term response to allergens. AIT has been shown to play a role in arresting the 'allergic march' in young people, which reduces the risk of developing asthmatic clinical manifestations. Although RCTs are considered the gold standard for evaluating the efficacy and safety of AIT, their duration is usually too short (seldom lasting more than 1 year) to assess the long-term effects of AIT. Several long-term studies show that AIT's effect depends strongly on its use duration.

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过敏原免疫疗法的现实证据。
综述目的:仅靠随机对照试验(RCT)无法全面了解过敏原免疫疗法(AIT)治疗过敏性呼吸道疾病的长期有效性和安全性。然而,作为登记处设计的真实世界研究可以对随机对照试验起到补充作用:摘要:AIT 是唯一一种能够诱导耐受并对过敏原产生长期反应的改变病情的治疗方法。事实证明,AIT 在阻止年轻人的 "过敏进程 "方面发挥了作用,从而降低了出现哮喘临床表现的风险。虽然 RCT 被认为是评估 AIT 疗效和安全性的黄金标准,但其持续时间通常太短(很少超过 1 年),无法评估 AIT 的长期效果。一些长期研究表明,AIT 的效果在很大程度上取决于其使用时间的长短。
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来源期刊
CiteScore
5.90
自引率
3.60%
发文量
109
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on one to three topics, every issue of Current Opinion in Allergy and Clinical Immunology delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as upper airway disease; mechanisms of allergy and adult asthma; paediatric asthma and development of atopy; food and drug allergies; and immunotherapy.
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