Polydopamine-Based Biomaterials in Orthopedic Therapeutics: Properties, Applications, and Future Perspectives.

IF 4.7 2区医学 Q1 CHEMISTRY, MEDICINAL Drug Design, Development and Therapy Pub Date : 2024-08-26 eCollection Date: 2024-01-01 DOI:10.2147/DDDT.S473007

Min Zhang, Man Mi, Zilong Hu, Lixian Li, Zhiping Chen, Xiang Gao, Di Liu, Bilian Xu, Yanzhi Liu

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Abstract

Polydopamine is a versatile and modifiable polymer, known for its excellent biocompatibility and adhesiveness. It can also be engineered into a variety of nanoparticles and biomaterials for drug delivery, functional modification, making it an excellent choice to enhance the prevention and treatment of orthopedic diseases. Currently, the application of polydopamine biomaterials in orthopedic disease prevention and treatment is in its early stages, despite some initial achievements. This article aims to review these applications to encourage further development of polydopamine for orthopedic therapeutic needs. We detail the properties of polydopamine and its biomaterial types, highlighting its superior performance in functional modification on nanoparticles and materials. Additionally, we also explore the challenges and future prospects in developing optimal polydopamine biomaterials for clinical use in orthopedic disease prevention and treatment.

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骨科治疗中的聚多巴胺基生物材料：特性、应用和未来展望》。

聚多巴胺是一种用途广泛的可改性聚合物，以其出色的生物相容性和粘合性而著称。它还可以被设计成各种纳米颗粒和生物材料，用于药物输送和功能修饰，是加强骨科疾病预防和治疗的绝佳选择。目前，聚多巴胺生物材料在骨科疾病预防和治疗中的应用虽然取得了一些初步成效，但仍处于早期阶段。本文旨在回顾这些应用，以鼓励进一步开发聚多巴胺，满足骨科治疗的需要。我们详细介绍了聚多巴胺的特性及其生物材料类型，强调了其在纳米颗粒和材料功能修饰方面的卓越性能。此外，我们还探讨了开发最佳聚多巴胺生物材料用于临床骨科疾病预防和治疗所面临的挑战和未来前景。

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来源期刊

Drug Design, Development and Therapy CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

9.00

自引率

0.00%

发文量

382

审稿时长

>12 weeks

期刊介绍： Drug Design, Development and Therapy is an international, peer-reviewed, open access journal that spans the spectrum of drug design, discovery and development through to clinical applications. The journal is characterized by the rapid reporting of high-quality original research, reviews, expert opinions, commentary and clinical studies in all therapeutic areas. Specific topics covered by the journal include: Drug target identification and validation Phenotypic screening and target deconvolution Biochemical analyses of drug targets and their pathways New methods or relevant applications in molecular/drug design and computer-aided drug discovery* Design, synthesis, and biological evaluation of novel biologically active compounds (including diagnostics or chemical probes) Structural or molecular biological studies elucidating molecular recognition processes Fragment-based drug discovery Pharmaceutical/red biotechnology Isolation, structural characterization, (bio)synthesis, bioengineering and pharmacological evaluation of natural products** Distribution, pharmacokinetics and metabolic transformations of drugs or biologically active compounds in drug development Drug delivery and formulation (design and characterization of dosage forms, release mechanisms and in vivo testing) Preclinical development studies Translational animal models Mechanisms of action and signalling pathways Toxicology Gene therapy, cell therapy and immunotherapy Personalized medicine and pharmacogenomics Clinical drug evaluation Patient safety and sustained use of medicines.