Clinical Characteristics and Prognosis of ICU-Admitted Patients with Guillain-Barre Syndrome: A Report from a Large Teaching Hospital in South Iran.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2024-08-01 DOI:10.30476/ijms.2023.99401.3144
Vida Naderi-Boldaji, Farid Zand, Naeimehossadat Asmarian, Hoda Marbooti, Mansoor Masjedi, Seyedeh Maryam Tabibzadeh, Zahra Esmaeilinezhad, Masoume Nazeri
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Abstract

Background: Guillain-Barre Syndrome (GBS) is the most prevalent acute peripheral polyneuropathy disorder. The disparities between populations and variations in the major risk factors highlight the importance of country-specific studies. This study aimed to report clinical characteristics and outcomes of ICU-admitted patients with GBS in an academic medical center in Iran.

Methods: The data were collected retrospectively from all patients with GBS admitted to Namazi Hospital, affiliated with Shiraz University of Medical Sciences, (Shiraz, Iran), between March 2016 to March 2021. Specialized neurological information and the Acute Physiology and Chronic Health Evaluation (APACHE II) score were recorded. The SPSS software was used to analyze the data. The analyzed data were reported as numbers and percentages, or mean±SD, or median(Interquartile).

Results: The study included 132 GBS patients, with an average age of 47.87±15.4 years and a male-to-female ratio of 1.69:1. More than half of the patients (58.5%) were classified as having an axonal disease. In patients with axonal illness, 51.4% of patients had lower limb powers<3, while only 36% of those had the demyelinating disease. This group also required mechanical ventilation more frequently (54% vs. 46%) and for a longer duration (26 [9-37] vs. 10 [1-61]) days. Pneumonia and sepsis were each observed in 16% of patients, and 12% developed a urinary tract infection. The most common type of GBS was acute inflammatory demyelinating polyneuropathy (AIDP). Only 6 (3.8%) patients died.

Conclusion: The axonal type of GBS was more frequent, and these patients required mechanical ventilation more frequently and for a longer duration than those in other electrophysiological categories. A preprint version of the manuscript is available at DOI: https://doi.org/10.21203/rs.3.rs-2181605/v1.

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入住重症监护病房的格林-巴利综合征患者的临床特征和预后:来自伊朗南部一家大型教学医院的报告。
背景:格林-巴利综合征(GBS)是最常见的急性周围多发性神经病。不同人群之间的差异和主要风险因素的不同凸显了国别研究的重要性。本研究旨在报告伊朗一家学术医疗中心收治的重症监护室 GBS 患者的临床特征和预后:方法:研究人员回顾性收集了2016年3月至2021年3月期间伊朗设拉子医科大学附属纳马济医院(伊朗设拉子)收治的所有GBS患者的数据。记录了专业神经信息和急性生理学和慢性健康评估(APACHE II)评分。数据采用 SPSS 软件进行分析。结果:研究共纳入 132 例 GBS 患者,平均年龄(47.87±15.4)岁,男女比例为 1.69:1。一半以上的患者(58.5%)被归类为轴索疾病。在轴索病患者中,51.4%的患者患有下肢瘫痪:结论:轴索型 GBS 的发病率更高,与其他电生理类型的患者相比,这些患者需要机械通气的频率更高、持续时间更长。该手稿的预印本可在以下网站获取:DOI: https://doi.org/10.21203/rs.3.rs-2181605/v1。
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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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