Magnetic Resonance Imaging to Detect Structural Brain Changes in Huntington's Disease: A Review of Data from Mouse Models.

IF 2.1 Q3 NEUROSCIENCES Journal of Huntington's disease Pub Date : 2024-01-01 DOI:10.3233/JHD-240045
Jenna Hanrahan, Drew P Locke, Lindsay S Cahill
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Abstract

Structural magnetic resonance imaging (MRI) is a powerful tool to visualize 3D neuroanatomy and assess pathology and disease progression in neurodegenerative disorders such as Huntington's disease (HD). The development of mouse models of HD that reproduce many of the psychiatric, motor and cognitive impairments observed in human HD has improved our understanding of the disease and provided opportunities for testing novel therapies. Similar to the clinical scenario, MRI of mouse models of HD demonstrates onset and progression of brain pathology. Here, we provided an overview of the articles that used structural MRI in mouse models of HD to date, highlighting the differences between studies and models and describing gaps in the current state of knowledge and recommendations for future studies.

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磁共振成像检测亨廷顿氏病的脑结构变化:小鼠模型数据回顾。
结构磁共振成像(MRI)是一种功能强大的工具,可用于观察三维神经解剖,评估亨廷顿氏病(HD)等神经退行性疾病的病理和疾病进展。HD小鼠模型能再现人类HD中观察到的许多精神、运动和认知障碍,它的开发提高了我们对该疾病的认识,并为测试新型疗法提供了机会。与临床情况类似,HD 小鼠模型的核磁共振成像显示了大脑病理学的发生和发展。在此,我们概述了迄今为止在HD小鼠模型中使用结构性核磁共振成像的文章,强调了不同研究和模型之间的差异,并描述了当前知识水平的差距和对未来研究的建议。
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来源期刊
CiteScore
4.80
自引率
9.70%
发文量
60
期刊最新文献
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