Expression and significance of CEMIP and CYP11B2 in serum in women with foetal growth restriction.

IF 0.9 4区医学 Q4 OBSTETRICS & GYNECOLOGY Journal of Obstetrics and Gynaecology Pub Date : 2024-12-01 Epub Date: 2024-09-01 DOI:10.1080/01443615.2024.2389169

Yang Yue, Fang Fang Zhou, Jia Rong Zhang, Fu Xu

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Abstract

Background: Foetal growth restriction (FGR) occurs when a foetus fails to reach its growth potential. This observational study assessed the expression and significance of cell migration-including protein (CEMIP) and aldosterone synthase (CYP11B2) in the serum of pregnant women with FGR.

Methods: 40 singleton FGR-suffered pregnant women, as well as 40 normal singleton pregnant women, were enrolled. The expression of CEMIP and CYP11B2 in serum was detected in early pregnancy. The correlations between parameters were evaluated. The predictive variables for FGR were determined. The diagnostic value of CEMIP and CYP11B2 for FGR was analysed.

Results: CEMIP and CYP11B2 mRNA expression in the serum of pregnant women with FGR decreased (both P < 0.001). CEMIP (95%CI: 0.802-0.921, P < 0.001) and CYP11B2 (95%CI: 0.795-0.907, P < 0.001) mRNA expression in serum and soluble fms like tyrosine kinase-1 (sFLT1)/placental growth factor (PlGF) ratio (95%CI: 0.866-0.974, P < 0.001) were independent predictors of FGR, and CEMIP (r = -0.578, P = 0.001) and CYP11B2 (r = -0.602, P < 0.001) mRNA expression in serum were negatively correlated with sFLT1/PlGF ratio. CEMIP (AUC = 0.741) and CYP11B2 (AUC = 0.764) mRNA expression in serum had good diagnostic value for FGR.

Conclusion: The expression of CEMIP and CYP11B2 is reduced in the serum of pregnant women with FGR and may become new diagnostic markers for FGR.

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胎儿生长受限妇女血清中 CEMIP 和 CYP11B2 的表达及其意义。

背景：胎儿生长受限（FGR）是指胎儿无法达到其生长潜能。这项观察性研究评估了FGR孕妇血清中包括细胞迁移蛋白（CEMIP）和醛固酮合成酶（CYP11B2）的表达及其意义。在妊娠早期检测血清中 CEMIP 和 CYP11B2 的表达。评估了各参数之间的相关性。确定了 FGR 的预测变量。分析了 CEMIP 和 CYP11B2 对 FGR 的诊断价值：结果：FGR 孕妇血清中 CEMIP 和 CYP11B2 mRNA 表达量减少（均为 P P P P r = -0.578，P = 0.001），CYP11B2（r = -0.602，P 结论：FGR 孕妇血清中 CEMIP 和 CYP11B2 mRNA 表达量减少（均为 P P P P r = -0.578，P = 0.001）：CEMIP和CYP11B2在FGR孕妇血清中的表达量减少，可能成为FGR的新诊断标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology 医学-妇产科学

CiteScore

2.40

自引率

7.70%

发文量

398

审稿时长

6 months

期刊介绍： Journal of Obstetrics and Gynaecology represents an established forum for the entire field of obstetrics and gynaecology, publishing a broad range of original, peer-reviewed papers, from scientific and clinical research to reviews relevant to practice. It also includes occasional supplements on clinical symposia. The journal is read widely by trainees in our specialty and we acknowledge a major role in education in Obstetrics and Gynaecology. Past and present editors have recognized the difficulties that junior doctors encounter in achieving their first publications and spend time advising authors during their initial attempts at submission. The journal continues to attract a world-wide readership thanks to the emphasis on practical applicability and its excellent record of drawing on an international base of authors.