Clinical research in endometrial cancer: consensus recommendations from the Gynecologic Cancer InterGroup.

IF 41.6 1区 医学 Q1 ONCOLOGY Lancet Oncology Pub Date : 2024-09-01 DOI:10.1016/S1470-2045(24)00192-X
Carien L Creutzberg, Jae-Weon Kim, Gemma Eminowicz, Emma Allanson, Lauriane Eberst, Se Ik Kim, Remi A Nout, Jeong-Yeol Park, Domenica Lorusso, Linda Mileshkin, Petronella B Ottevanger, Alison Brand, Delia Mezzanzanica, Amit Oza, Val Gebski, Bhavana Pothuri, Tania Batley, Carol Gordon, Tina Mitra, Helen White, Brooke Howitt, Xavier Matias-Guiu, Isabelle Ray-Coquard, David Gaffney, William Small, Austin Miller, Nicole Concin, Matthew A Powell, Gavin Stuart, Michael A Bookman
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Abstract

The Gynecologic Cancer InterGroup (GCIG) Endometrial Cancer Consensus Conference on Clinical Research (ECCC) was held in Incheon, South Korea, Nov 2-3, 2023. The aims were to develop consensus statements for future trials in endometrial cancer to achieve harmonisation on design elements, select important questions, and identify unmet needs. All 33 GCIG member groups participated in the development, refinement, and finalisation of 18 statements within four topic groups, addressing adjuvant treatment in high-risk disease; treatment for metastatic and recurrent disease; trial designs for rare endometrial cancer subgroups and special circumstances; and specific methodology and adaptation for trials in low-resource settings. In addition, eight areas of unmet need were identified. This was the first GCIG Consensus Conference to include patient advocates and an expert on inclusion, diversity, equity, and access to take part in all aspects of the process and output. Four early-career investigators were also selected for participation, ensuring that they represented different GCIG member groups and regions. Unanimous consensus was obtained for 16 of the 18 statements, with 97% concordance for the remaining two. Using the described methodology from previous Ovarian Cancer Consensus Conferences, this conference did not require even one minority statement. The high acceptance rate following active involvement in the preparation, discussion, and refinement of the statements by all representatives confirmed the consensus progress within a global academic setting, and the expectation that the ECCC will lead to greater harmonisation, actualisation, inclusion, and resolution of unmet needs in clinical research for individuals living with and beyond endometrial cancer worldwide.

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子宫内膜癌的临床研究:妇科癌症国际小组的共识建议。
妇科癌症国际小组(GCIG)子宫内膜癌临床研究共识会议(ECCC)于 2023 年 11 月 2 日至 3 日在韩国仁川举行。会议旨在为未来的子宫内膜癌试验制定共识声明,以统一设计要素、选择重要问题并确定未满足的需求。全球子宫内膜癌小组的所有 33 个成员小组都参与了四个专题小组 18 项声明的制定、完善和定稿工作,这些声明涉及高危疾病的辅助治疗、转移性和复发性疾病的治疗、罕见子宫内膜癌亚组和特殊情况下的试验设计,以及低资源环境下试验的具体方法和适应性。此外,还确定了八个尚未满足需求的领域。这是 GCIG 共识会议首次邀请患者权益倡导者和一位包容性、多样性、公平性和可及性方面的专家参与会议进程和成果的各个方面。会议还挑选了四位早期职业研究人员参加,确保他们代表不同的 GCIG 成员团体和地区。在 18 项声明中,有 16 项获得了一致同意,其余两项的同意率为 97%。采用以往卵巢癌共识会议的方法,本次会议甚至不需要一份少数人声明。所有代表都积极参与了声明的准备、讨论和完善工作,其较高的接受率证实了在全球学术环境中取得的共识进展,并期待 ECCC 将促进协调、实现、包容和解决全球子宫内膜癌患者和其他患者在临床研究中未得到满足的需求。
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来源期刊
Lancet Oncology
Lancet Oncology 医学-肿瘤学
CiteScore
62.10
自引率
1.00%
发文量
913
审稿时长
3-8 weeks
期刊介绍: The Lancet Oncology is a trusted international journal that addresses various topics in clinical practice, health policy, and global oncology. It covers a wide range of cancer types, including breast, endocrine system, gastrointestinal, genitourinary, gynaecological, haematological, head and neck, neurooncology, paediatric, thoracic, sarcoma, and skin cancers. Additionally, it includes articles on epidemiology, cancer prevention and control, supportive care, imaging, and health-care systems. The journal has an Impact Factor of 51.1, making it the leading clinical oncology research journal worldwide. It publishes different types of articles, such as Articles, Reviews, Policy Reviews, Personal Views, Clinical Pictures, Comments, Correspondence, News, and Perspectives. The Lancet Oncology also collaborates with societies, governments, NGOs, and academic centers to publish Series and Commissions that aim to drive positive changes in clinical practice and health policy in areas of global oncology that require attention.
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