Improving individualised therapies in localised gastro-oesophageal adenocarcinoma.

IF 41.6 1区 医学 Q1 ONCOLOGY Lancet Oncology Pub Date : 2024-09-01 DOI:10.1016/S1470-2045(24)00180-3
Magali Svrcek, Thibault Voron, Thierry André, Elizabeth C Smyth, Christelle de la Fouchardière
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Abstract

Despite our increased understanding of the biological and molecular aspects of gastro-oesophageal tumourigenesis, the identification of prognostic or predictive factors remains challenging. Patients with resectable gastric and oesophageal adenocarcinoma are often treated similarly after surgical resection, regardless of their tumour biology, clinical characteristics, and histological treatment response. Substantial progress has been made in the past 5 years in managing patients with gastric or oesophageal adenocarcinoma, including the use of immune checkpoint inhibitors and new targeted therapies, leading to substantial improvements in clinical outcomes. These advancements have primarily been established in advanced and metastatic disease, while the management framework for local and locoregional disease is just beginning to shift. We provide an overview of existing data on biomarkers and tumour-related and host-related factors that are relevant to stratify patients into low-risk and high-risk recurrence groups, both before and after surgery, paving the way for more personalised treatment approaches.

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改进局部胃食管腺癌的个体化疗法。
尽管我们对胃食管肿瘤发生的生物学和分子方面有了更多的了解,但确定预后或预测因素仍然具有挑战性。可切除的胃腺癌和食管腺癌患者在手术切除后通常会接受类似的治疗,无论其肿瘤生物学特性、临床特征和组织学治疗反应如何。过去 5 年中,在治疗胃或食管腺癌患者方面取得了重大进展,包括使用免疫检查点抑制剂和新型靶向疗法,从而大大改善了临床疗效。这些进展主要针对晚期和转移性疾病,而针对局部和局部区域疾病的管理框架才刚刚开始转变。我们概述了现有的生物标志物、肿瘤相关因素和宿主相关因素的数据,这些数据有助于在手术前后将患者分为低风险和高风险复发组,为更个性化的治疗方法铺平道路。
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来源期刊
Lancet Oncology
Lancet Oncology 医学-肿瘤学
CiteScore
62.10
自引率
1.00%
发文量
913
审稿时长
3-8 weeks
期刊介绍: The Lancet Oncology is a trusted international journal that addresses various topics in clinical practice, health policy, and global oncology. It covers a wide range of cancer types, including breast, endocrine system, gastrointestinal, genitourinary, gynaecological, haematological, head and neck, neurooncology, paediatric, thoracic, sarcoma, and skin cancers. Additionally, it includes articles on epidemiology, cancer prevention and control, supportive care, imaging, and health-care systems. The journal has an Impact Factor of 51.1, making it the leading clinical oncology research journal worldwide. It publishes different types of articles, such as Articles, Reviews, Policy Reviews, Personal Views, Clinical Pictures, Comments, Correspondence, News, and Perspectives. The Lancet Oncology also collaborates with societies, governments, NGOs, and academic centers to publish Series and Commissions that aim to drive positive changes in clinical practice and health policy in areas of global oncology that require attention.
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