The effect of posture on the age dependence of neurovascular coupling.

IF 2.2 Q3 PHYSIOLOGY Physiological Reports Pub Date : 2024-09-01 DOI:10.14814/phy2.70031

James D Ball, Aaron Davies, Dewakar Gurung, Alex Mankoo, Ronney Panerai, Jatinder S Minhas, Thompson Robinson, Lucy Beishon

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Abstract

Previous studies report contradicting age-related neurovascular coupling (NVC). Few studies assess postural effects, but less investigate relationships between age and NVC within different postures. Therefore, this study investigated the effect of age on NVC in different postures with varying cognitive stimuli. Beat-to-beat blood pressure, heart rate and end-tidal carbon dioxide were assessed alongside middle and posterior cerebral artery velocities (MCAv and PCAv, respectively) using transcranial Doppler ultrasonography in 78 participants (31 young-, 23 middle- and 24 older-aged) with visuospatial (VST) and attention tasks (AT) in various postures at two timepoints (T2 and T3). Between-group significance testing utilized one-way analysis-of-variance (ANOVA) (Tukey post-hoc). Mixed three-way/one-way ANOVAs explored task, posture, and age interactions. Significant effects of posture on NVC were driven by a 3.8% increase from seated to supine. For AT, mean supine %MCAv increase was greatest in younger (5.44%) versus middle (0.12%) and older-age (0.09%) at T3 (p = 0.005). For VST, mean supine %PCAv increase was greatest at T2 and T3 in middle (10.99%/10.12%) and older-age (17.36%/17.26%) versus younger (9.44%/8.89%) (p = 0.004/p = 0.002). We identified significant age-related NVC effects with VST-induced hyperactivation. This may reflect age-related compensatory processes in supine. Further work is required, using complex stimuli while standing/walking, examining NVC, aging and falls.

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姿势对神经血管耦合年龄依赖性的影响。

以往的研究报告显示，与年龄相关的神经血管耦合（NVC）相互矛盾。很少有研究评估姿势的影响，但更少研究不同姿势下年龄与神经血管耦合的关系。因此，本研究调查了不同认知刺激下不同姿势下年龄对神经血管耦合的影响。在两个时间点（T2 和 T3），对 78 名参与者（31 名年轻人、23 名中年人和 24 名老年人）在不同姿势下进行视觉空间任务（VST）和注意力任务（AT）时的搏动血压、心率和潮气末二氧化碳以及大脑中动脉和后动脉速度（分别为 MCAv 和 PCAv）进行了经颅多普勒超声波评估。组间显著性检验采用单因素方差分析（Tukey post-hoc）。三方/单方混合方差分析探讨了任务、姿势和年龄的交互作用。从坐姿到仰卧，姿势对 NVC 的显著影响增加了 3.8%。对于 AT，在 T3 阶段，年轻（5.44%）与中年（0.12%）和老年（0.09%）相比，平均仰卧百分比 MCAv 增加幅度最大（p = 0.005）。就 VST 而言，在 T2 和 T3 阶段，中年（10.99%/10.12%）和老年（17.36%/17.26%）与年轻人（9.44%/8.89%）相比，平均仰卧位 %PCAv 增加幅度最大（p = 0.004/p = 0.002）。我们发现了与年龄相关的 NVC 效应与 VST 诱导的过度激活。这可能反映了仰卧时与年龄相关的代偿过程。我们还需要在站立/行走时使用复杂刺激，进一步研究 NVC、衰老和跌倒。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiological Reports PHYSIOLOGY-

CiteScore

4.20

自引率

4.00%

发文量

374

审稿时长

9 weeks

期刊介绍： Physiological Reports is an online only, open access journal that will publish peer reviewed research across all areas of basic, translational, and clinical physiology and allied disciplines. Physiological Reports is a collaboration between The Physiological Society and the American Physiological Society, and is therefore in a unique position to serve the international physiology community through quick time to publication while upholding a quality standard of sound research that constitutes a useful contribution to the field.