Role of Platelets and Their Interaction with Immune Cells in Venous Thromboembolism.

IF 3.6 2区医学 Q2 HEMATOLOGY Seminars in thrombosis and hemostasis Pub Date : 2024-08-30 DOI:10.1055/s-0044-1789022

Zhao Zhang, Xianghui Zhou, Xin Zhou, Zhipeng Cheng, Yu Hu

{"title":"Role of Platelets and Their Interaction with Immune Cells in Venous Thromboembolism.","authors":"Zhao Zhang, Xianghui Zhou, Xin Zhou, Zhipeng Cheng, Yu Hu","doi":"10.1055/s-0044-1789022","DOIUrl":null,"url":null,"abstract":"<p><p>Venous thromboembolism (VTE) represents a significant global health challenge, ranking as the third leading cause of cardiovascular-related mortality. VTE pervades diverse clinical specialties, posing substantial risks to patient well-being and imposing considerable economic strains on health care systems. While platelets have long been recognized as pivotal players in hemostasis, emerging evidence underscores their multifaceted immune functions and their capacity to engage in crosstalk with other immune cells, such as neutrophils, thereby fostering immune-related thrombosis. Notably, investigations have elucidated the pivotal role of platelets in the pathogenesis of VTE. This review provides a comprehensive overview of platelet physiology, encompassing their activation, secretion dynamics, and implications in VTE. Moreover, it delineates the impact of platelet interactions with various immune cells on the initiation and progression of VTE, explores the correlation between platelet-related laboratory markers and VTE, and elucidates the role of platelets in thrombosis regression.</p>","PeriodicalId":21673,"journal":{"name":"Seminars in thrombosis and hemostasis","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in thrombosis and hemostasis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/s-0044-1789022","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Venous thromboembolism (VTE) represents a significant global health challenge, ranking as the third leading cause of cardiovascular-related mortality. VTE pervades diverse clinical specialties, posing substantial risks to patient well-being and imposing considerable economic strains on health care systems. While platelets have long been recognized as pivotal players in hemostasis, emerging evidence underscores their multifaceted immune functions and their capacity to engage in crosstalk with other immune cells, such as neutrophils, thereby fostering immune-related thrombosis. Notably, investigations have elucidated the pivotal role of platelets in the pathogenesis of VTE. This review provides a comprehensive overview of platelet physiology, encompassing their activation, secretion dynamics, and implications in VTE. Moreover, it delineates the impact of platelet interactions with various immune cells on the initiation and progression of VTE, explores the correlation between platelet-related laboratory markers and VTE, and elucidates the role of platelets in thrombosis regression.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

血小板及其与免疫细胞的相互作用在静脉血栓栓塞症中的作用

静脉血栓栓塞症（VTE）是全球健康面临的重大挑战，是心血管相关死亡的第三大主要原因。静脉血栓栓塞遍布各临床专科，给患者的健康带来巨大风险，并给医疗保健系统带来巨大的经济压力。长期以来，血小板一直被认为是止血过程中的关键角色，而新出现的证据则强调了其多方面的免疫功能及其与中性粒细胞等其他免疫细胞发生串扰的能力，从而促进了与免疫相关的血栓形成。值得注意的是，研究已经阐明了血小板在 VTE 发病机制中的关键作用。本综述全面概述了血小板的生理学，包括其活化、分泌动态以及在 VTE 中的影响。此外，它还描述了血小板与各种免疫细胞的相互作用对 VTE 发生和发展的影响，探讨了血小板相关实验室指标与 VTE 之间的相关性，并阐明了血小板在血栓消退中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Seminars in thrombosis and hemostasis 医学-外周血管病

CiteScore

8.80

自引率

21.10%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Seminars in Thrombosis and Hemostasis is a topic driven review journal that focuses on all issues relating to hemostatic and thrombotic disorders. As one of the premiere review journals in the field, Seminars in Thrombosis and Hemostasis serves as a comprehensive forum for important advances in clinical and laboratory diagnosis and therapeutic interventions. The journal also publishes peer reviewed original research papers. Seminars offers an informed perspective on today''s pivotal issues, including hemophilia A & B, thrombophilia, gene therapy, venous and arterial thrombosis, von Willebrand disease, vascular disorders and thromboembolic diseases. Attention is also given to the latest developments in pharmaceutical drugs along with treatment and current management techniques. The journal also frequently publishes sponsored supplements to further highlight emerging trends in the field.