Effects of a Prophylactic Treatment with Horseradish Root and Nasturtium Herb on Urinary Tract Infections in Individuals with Chronic Neurogenic Lower Urinary Tract Dysfunction: A Retrospective Cohort Study.

IF 1.5 4区医学 Q3 UROLOGY & NEPHROLOGY Urologia Internationalis Pub Date : 2024-08-31 DOI:10.1159/000541248

Andrea Martina Bieri, Jens Wöllner, Jürgen Pannek, Jörg Krebs

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Abstract

Introduction: Recurrent urinary tract infections (UTIs) are common in individuals with neurogenic lower urinary tract dysfunction (NLUTD) and greatly affect their quality of life. There is currently no established prophylactic measure based on evidence. We have therefore evaluated the effects of a horseradish root and nasturtium herb product on the frequency of UTIs in a retrospective cohort.

Methods: Clinical data of patients with chronic NLUTD who were receiving the phytotherapeuticum for at least 12 months were analyzed. The number of UTIs was categorized as no UTIs, sporadic UTIs (1-2/year) and recurrent UTIs (≥3/year). The change in the annual number of patient-reported symptomatic UTIs and antibiotic prescriptions was investigated.

Results: Data of 43 individuals (mean age 49 ± 13 years, median NLUTD duration 17.9 years) were analyzed. The proportion of individuals with recurrent UTIs decreased significantly (p < 0.0001) from 58.1% (42.1-73.0%) to 23.3% (11.8-38.6%) during phytotherapy, whereas the proportion of individuals without UTIs increased significantly (p = 0.001) from 14.0% (5.3-27.9%) to 39.5% (25.0-55.6%). In addition, there was a significant (p = 0.008) decrease in the number of antibiotic prescriptions.

Conclusion: Prophylactic treatment with horseradish root and nasturtium herb seems to be a promising option for the prevention of UTIs.

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使用辣根和龙葵草预防性治疗对慢性神经源性下尿路功能障碍患者尿路感染的影响--一项回顾性队列研究。

导言：复发性尿路感染（UTI）是神经源性下尿路功能障碍（NLUTD）患者的常见病，严重影响他们的生活质量。目前还没有基于证据的既定预防措施。因此，我们在一个回顾性队列中评估了辣根和金莲花药草产品对UTI发生频率的影响：方法：分析了接受植物疗法至少 12 个月的慢性 NLUTD 患者的临床数据。UTI次数分为无UTI、偶发性UTI（1-2次/年）和复发性UTI（≥3次/年）。研究调查了患者报告的无症状 UTI 和抗生素处方每年数量的变化：分析了 43 名患者（平均年龄为 49±13 岁，中位 NLUTD 病程为 17.9 年）的数据。在植物疗法期间，复发性 UTIs 的比例从 58.1%（42.1-73.0%）显著下降（p<0.0001）至 23.3%（11.8-38.6%），而无 UTIs 的比例则从 14.0%（5.3-27.9%）显著增加（p=0.001）至 39.5%（25.0-55.6%）。此外，抗生素处方的数量也明显减少（p=0.008）：结论：使用辣根和金莲花药草进行预防性治疗似乎是预防UTI的一个很有前景的选择。

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来源期刊

Urologia Internationalis 医学-泌尿学与肾脏学

CiteScore

3.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.