Coronary bifurcation lesion treatment with the BioMime™ Branch sirolimus-eluting coronary side-branch stent system: A single-center experience.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Revascularization Medicine Pub Date : 2024-08-28 DOI:10.1016/j.carrev.2024.08.018
Antonio L Bartorelli, Giovanni Monizzi, Luca Grancini, Emanuele Gallinoro, Angelo Mastrangelo, Vincenzo Mallia, Franco Fabbiocchi
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Abstract

Background: Coronary bifurcation lesions (CBL) comprise 15 %-20 % of percutaneous coronary procedures and remain a challenge despite advances in stent and interventional techniques. The BioMime™ Branch sirolimus-eluting coronary side-branch stent (BBSES) is specifically designed for CBL treatment in conjunction with a standard drug-eluting stent (DES). We report the first single-center experience of treating complex CBL with the novel BBSES.

Methods: This is a retrospective, single-center study involving consecutive prospectively identified patients who underwent treatment of true CBL with the BBSES. The protocol included BBSES+DES implantation in the CBL and simultaneous final kissing balloon inflation.

Results: Fifty-eight CBL were treated in 58 consecutive patients (89.6 % men, mean age 69.0 ± 9.5 years) presenting primarily with stable angina (84.4 %) and true (Medina 1,1,1,) CBL. Procedural success was 100 % without major adverse cardiac events (MACE). At a median follow-up of 18 months, one sudden death was reported that was accounted as possible late stent thrombosis. One patient had spontaneous myocardial infarction due to subacute thrombosis of a DES implanted in the main vessel proximally to the BBSES before the index procedure. Another patient was hospitalized for atrial fibrillation.

Conclusions: This is the first clinical experience to date of true CBL treatment with the BBSES demonstrating high procedural success, no in-hospital MACE and sustained clinical results at a median follow-up of 18 months.

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使用 BioMime™ 支西罗莫司洗脱冠状动脉侧支支架系统治疗冠状动脉分叉病变:单中心经验。
背景:冠状动脉分叉病变(CBL)占经皮冠状动脉手术的 15%-20%,尽管支架和介入技术不断进步,但它仍然是一项挑战。BioMime™ 支西罗莫司洗脱冠状动脉侧支支架(BBSES)是专为结合标准药物洗脱支架(DES)治疗 CBL 而设计的。我们报告了首个使用新型 BBSES 治疗复杂 CBL 的单中心经验:这是一项回顾性单中心研究,涉及连续接受 BBSES 治疗真正 CBL 的前瞻性患者。研究方案包括在 CBL 中植入 BBSES+DES 并同时进行最后的接吻球囊充气:58 名连续患者(89.6% 为男性,平均年龄为 69.0 ± 9.5 岁)接受了 58 例 CBL 治疗,这些患者主要表现为稳定型心绞痛(84.4%)和真性(Medina 1,1,1,)CBL。手术成功率为 100%,无重大心脏不良事件 (MACE)。中位随访时间为 18 个月,有一例猝死被认为可能是晚期支架血栓形成。一名患者在指数手术前因植入 BBSES 近端主血管的 DES 出现亚急性血栓而自发心肌梗死。另一名患者因心房颤动住院:这是迄今为止首次使用 BBSES 进行真正 CBL 治疗的临床经验,表明手术成功率高,无院内 MACE,并且在中位随访 18 个月后仍能保持临床效果。
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来源期刊
Cardiovascular Revascularization Medicine
Cardiovascular Revascularization Medicine CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
3.30
自引率
5.90%
发文量
687
审稿时长
36 days
期刊介绍: Cardiovascular Revascularization Medicine (CRM) is an international and multidisciplinary journal that publishes original laboratory and clinical investigations related to revascularization therapies in cardiovascular medicine. Cardiovascular Revascularization Medicine publishes articles related to preclinical work and molecular interventions, including angiogenesis, cell therapy, pharmacological interventions, restenosis management, and prevention, including experiments conducted in human subjects, in laboratory animals, and in vitro. Specific areas of interest include percutaneous angioplasty in coronary and peripheral arteries, intervention in structural heart disease, cardiovascular surgery, etc.
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