Comparative Atlas of SARS-CoV-2 Substitution Mutations: A Focus on Iranian Strains Amidst Global Trends.

IF 3.8 3区医学 Q2 VIROLOGY Viruses-Basel Pub Date : 2024-08-20 DOI:10.3390/v16081331

Mohammad Hadi Abbasian, Karim Rahimian, Mohammadamin Mahmanzar, Saleha Bayat, Donna Lee Kuehu, Mahsa Mollapour Sisakht, Bahman Moradi, Youping Deng

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Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new emerging coronavirus that caused coronavirus disease 2019 (COVID-19). Whole-genome tracking of SARS-CoV-2 enhanced our understanding of the mechanism of the disease, control, and prevention of COVID-19.

Methods: we analyzed 3368 SARS-CoV-2 protein sequences from Iran and compared them with 15.6 million global sequences in the GISAID database, using the Wuhan-Hu-1 strain as a reference.

Results: Our investigation revealed that NSP12-P323L, ORF9c-G50N, NSP14-I42V, membrane-A63T, Q19E, and NSP3-G489S were found to be the most frequent mutations among Iranian SARS-CoV-2 sequences. Furthermore, it was observed that more than 94% of the SARS-CoV-2 genome, including NSP7, NSP8, NSP9, NSP10, NSP11, and ORF8, had no mutations when compared to the Wuhan-Hu-1 strain. Finally, our data indicated that the ORF3a-T24I, NSP3-G489S, NSP5-P132H, NSP14-I42V, envelope-T9I, nucleocapsid-D3L, membrane-Q19E, and membrane-A63T mutations might be responsible factors for the surge in the SARS-CoV-2 Omicron variant wave in Iran.

Conclusions: real-time genomic surveillance is crucial for detecting new SARS-CoV-2 variants, updating diagnostic tools, designing vaccines, and understanding adaptation to new environments.

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SARS-CoV-2 替代突变比较图谱：在全球趋势中关注伊朗菌株

背景：严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）是一种新出现的冠状病毒，它引起了 2019 年冠状病毒病（COVID-19）。对SARS-CoV-2的全基因组追踪增强了我们对COVID-19的发病机制、控制和预防的理解。方法：我们分析了来自伊朗的3368个SARS-CoV-2蛋白序列，并以武汉-Hu-1毒株为参考，与GISAID数据库中的1560万个全球序列进行了比较：我们的调查发现，在伊朗的 SARS-CoV-2 序列中，NSP12-P323L、ORF9c-G50N、NSP14-I42V、membrane-A63T、Q19E 和 NSP3-G489S 是最常见的突变。此外，我们还观察到，与武汉-胡-1 株系相比，SARS-CoV-2 基因组中超过 94% 的部分（包括 NSP7、NSP8、NSP9、NSP10、NSP11 和 ORF8）没有发生突变。最后，我们的数据表明，ORF3a-T24I、NSP3-G489S、NSP5-P132H、NSP14-I42V、包膜-T9I、核帽-D3L、膜-Q19E和膜-A63T突变可能是导致伊朗SARS-CoV-2 Omicron变异株激增的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Viruses-Basel VIROLOGY-

CiteScore

7.30

自引率

12.80%

发文量

2445

审稿时长

1 months

期刊介绍： Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.