Mechanistic insights into cisplatin response in breast tumors: Molecular determinants and drug/nanotechnology-based therapeutic opportunities

IF 6.4 2区医学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Mutation Research-Reviews in Mutation Research Pub Date : 2024-07-01 DOI:10.1016/j.mrrev.2024.108513

Mehrdad Hashemi , Elaheh Mohandesi Khosroshahi , Mehrnaz Kalhor Chegini , Saba Asadi , Zahra Hamyani , Yasamin Alsadat Jafari , Fatemeh Rezaei , Ramtin Khodaparast Eskadehi , Kimia Kia Kojoori , Faranak Jamshidian , Noushin Nabavi , Mina Alimohammadi , Mohsen Rashidi , Behnaz Mahmoodieh , Ramin Khorrami , Afshin Taheriazam , Maliheh Entezari

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Abstract

Breast cancer continues to be a major global health challenge, driving the need for effective therapeutic strategies. Cisplatin, a powerful chemotherapeutic agent, is widely used in breast cancer treatment. However, its effectiveness is often limited by systemic toxicity and the development of drug resistance. This review examines the molecular factors that influence cisplatin response and resistance, offering crucial insights for the scientific community. It highlights the significance of understanding cisplatin resistance's genetic and epigenetic contributors, which could lead to more personalized treatment approaches. Additionally, the review explores innovative strategies to counteract cisplatin resistance, including combination therapies, nanoparticle-based drug delivery systems, and targeted therapies. These approaches are under intensive investigation and promise to enhance breast cancer treatment outcomes. This comprehensive discussion is a valuable resource to advance breast cancer therapeutics and address the challenge of cisplatin resistance.

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乳腺肿瘤中顺铂反应的机理透视：分子决定因素和基于药物/纳米技术的治疗机会。

乳腺癌仍然是全球健康面临的一大挑战，因此需要有效的治疗策略。顺铂是一种强效化疗药物，被广泛用于乳腺癌治疗。然而，其有效性往往受到全身毒性和耐药性发展的限制。这篇综述探讨了影响顺铂反应和耐药性的分子因素，为科学界提供了重要的见解。它强调了了解顺铂耐药性的遗传和表观遗传因素的重要性，这可能会带来更个性化的治疗方法。此外，该综述还探讨了应对顺铂耐药性的创新策略，包括联合疗法、纳米颗粒给药系统和靶向疗法。这些方法正在深入研究中，有望提高乳腺癌的治疗效果。本综述是推进乳腺癌治疗和应对顺铂耐药性挑战的宝贵资源。

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来源期刊

Mutation Research-Reviews in Mutation Research 生物-毒理学

CiteScore

12.20

自引率

1.90%

发文量

审稿时长

15.7 weeks

期刊介绍： The subject areas of Reviews in Mutation Research encompass the entire spectrum of the science of mutation research and its applications, with particular emphasis on the relationship between mutation and disease. Thus this section will cover advances in human genome research (including evolving technologies for mutation detection and functional genomics) with applications in clinical genetics, gene therapy and health risk assessment for environmental agents of concern.