SLAM family-mediated crosstalk between tumor and immune cells in the tumor microenvironment: a promising biomarker and a potential therapeutic target for immune checkpoint therapies.
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引用次数: 0
Abstract
Immune cells infiltrating the tumor microenvironment are physiologically important in controlling cancers. However, emerging studies have shown that cancer cells can evade immune surveillance and establish a balance in which these immune cells support tumor progression and therapeutic resistance. The signaling lymphocytic activation molecule family members have been recognized as mediators of tumor microenvironment interactions, and a promising therapeutic target for cancer immunotherapy. This review is focused on the role of SLAM family in tumor and immune cell interactions and discusses how such crosstalk affects tumor behavior. This will shed insight into the next step toward improving cancer immunotherapy.
肿瘤微环境中由 SLAM 家族介导的肿瘤与免疫细胞之间的串扰：一种有前景的生物标记物和免疫检查点疗法的潜在治疗靶点。
浸润肿瘤微环境的免疫细胞对控制癌症具有重要的生理作用。然而，新的研究表明，癌细胞可以逃避免疫监视，并建立一种平衡，在这种平衡中，这些免疫细胞支持肿瘤的发展和抗药性。信号淋巴细胞活化分子家族成员被认为是肿瘤微环境相互作用的介质，也是癌症免疫疗法的一个有希望的治疗靶点。本综述将重点探讨 SLAM 家族在肿瘤和免疫细胞相互作用中的作用，并讨论这种串扰如何影响肿瘤行为。这将为下一步改进癌症免疫疗法提供启示。
期刊介绍：
Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.
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