Renal cell carcinoma: entering the age of biomarkers.

IF 1.2 4区 医学 Q3 UROLOGY & NEPHROLOGY Canadian Journal of Urology Pub Date : 2024-08-01
Andrew S Iskandar, Kevin K Zarrabi, William J Tester
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Abstract

Introduction: Renal cell carcinoma is as the most prevalent form of kidney cancer, with the clear cell subtype comprising approximately 75% of cases. The identification of predictive and prognostic biomarkers has emerged as a crucial area of research within the field. Despite advancements in treatment, metastatic renal cell carcinoma presents formidable challenges, with survival rates heavily dependent upon the optimal choice of treatment.

Materials and methods: This review summarizes the current literature regarding the prognostic and predictive value of biomarkers in patients with renal cell carcinoma. We conducted a comprehensive literature search to identify studies that reference biomarkers of interest in this domain. We selected studies based on their relevance, publication date, and the quality of the research. Data from these selected papers were compiled and analyzed to provide an overview of the current understanding and advancements in the field. The findings were then synthesized into a concise discussion highlighting the state of biomarker research in renal cell carcinoma today.

Results and conclusions: While various nucleic acid and protein biomarkers have shown promise in other malignancies, their application in renal cell carcinoma remains limited by the lack of validated predictors. This review aims to highlight the pressing need for robust predictive and prognostic biomarkers in renal cell carcinoma to guide clinicians in tailoring optimal therapeutic strategies. The discussion encompasses the limitations of existing markers and underscores the significance of the most recent advancements within the field. Despite these strides, the clinical application of renal cell carcinoma biomarkers requires further study and validation.

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肾细胞癌:进入生物标志物时代。
简介肾细胞癌是最常见的肾癌,其中透明细胞亚型约占 75%。鉴定预测和预后生物标志物已成为该领域的一个重要研究领域。尽管在治疗方面取得了进步,但转移性肾细胞癌仍面临着严峻的挑战,其存活率在很大程度上取决于治疗方法的最佳选择:本综述总结了目前有关肾细胞癌患者生物标志物的预后和预测价值的文献。我们进行了一次全面的文献检索,以确定该领域相关生物标志物的参考研究。我们根据研究的相关性、发表日期和研究质量来选择研究。我们对所选论文中的数据进行了汇编和分析,以概述该领域目前的认识和进展。然后,我们将研究结果归纳为一个简明的讨论,突出强调了当今肾细胞癌生物标志物研究的现状:虽然各种核酸和蛋白质生物标志物在其他恶性肿瘤中的应用前景良好,但由于缺乏有效的预测指标,它们在肾细胞癌中的应用仍然受到限制。本综述旨在强调肾细胞癌迫切需要可靠的预测和预后生物标志物,以指导临床医生制定最佳治疗策略。讨论涵盖了现有标记物的局限性,并强调了该领域最新进展的重要性。尽管取得了这些进展,但肾细胞癌生物标志物的临床应用仍需进一步研究和验证。
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来源期刊
Canadian Journal of Urology
Canadian Journal of Urology UROLOGY & NEPHROLOGY-
CiteScore
1.90
自引率
0.00%
发文量
86
审稿时长
6-12 weeks
期刊介绍: The CJU publishes articles of interest to the field of urology and related specialties who treat urologic diseases.
期刊最新文献
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