Unveiling the Mysteries of the Blood-Brain Barrier: The Problem of the Brain/spinal Pharmacotherapy.

Aditya Walia, Amandeep Kaur, Randhir Singh, Nidhi Rani, Rajan Swami
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Abstract

The most critical issue impeding the development of innovative cerebrospinal medications is the blood-brain barrier (BBB). The BBB limits the ability of most medications to penetrate the brain to the CNS. The BBB structure and functions are summarized, with the physical barrier generated by endothelial tight junctions and the transport barrier formed by transporters within the membrane and vesicular processes. The functions of connected cells, particularly the end feet of astrocytic glial cells, microglia, and pericytes, are described. The drugs that cross the blood brain barrier are explained below along with their mechanisms. Some of the associated conditions and problems are given.

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揭开血脑屏障的神秘面纱:脑/脊髓药物疗法问题。
阻碍创新脑脊髓药物开发的最关键问题是血脑屏障 (BBB)。血脑屏障限制了大多数药物穿透大脑进入中枢神经系统的能力。本文总结了血脑屏障的结构和功能,包括由内皮紧密连接产生的物理屏障以及由膜内转运体和囊泡过程形成的转运屏障。介绍了连接细胞的功能,特别是星形胶质细胞、小胶质细胞和周细胞的末梢。下文将解释穿过血脑屏障的药物及其机制。还介绍了一些相关的情况和问题。
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