Detachable holographic acoustofluidic chip for striped acoustic field modulation and particle manipulation

IF 3.4 2区物理与天体物理 Q1 ACOUSTICS Applied Acoustics Pub Date : 2024-09-01 DOI:10.1016/j.apacoust.2024.110264

Luming Li , Mingyong Zhou , Lei Huang , Kai Luo , Bingyan Jiang

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Abstract

The development of detachable acoustofluidic devices is of great significance for disposable and cost-effective biological and chemical analysis. In this work, a highly integrated holographic acoustofluidic device based on acoustic holography and microfluidic chips was proposed to realize the modulation of striped acoustic field in microchannels. In the device, the chip is disposable and the transducer is reused. The acoustic hologram was fabricated by injection molding for efficient manufacturing and low cost. In addition, a multiphysics simulation model for holographic acoustofluidic chip was established to analyze the effect of acoustic field modulation and particle manipulation. Results showed that the acoustic pressure inside the microchannel of the device exhibits a clear striped distribution, and a linear arrangement of particles parallel and inclined to the extension direction of the channel wall can be achieved within 2 s. The distance between the arrangement lines in the target region was controlled at around 60 μm. The investigation of thermal effect validates the biocompatibility. The designed holographic acoustofluidic device presents a promising option for the manipulation, arrangement, and sorting of cells and other particles in microchannels.

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用于条纹声场调制和粒子操纵的可拆卸全息声流体芯片

开发可拆卸的声学流体装置对于一次性、低成本的生物和化学分析具有重要意义。本研究提出了一种基于声全息技术和微流控芯片的高度集成的全息声流体装置，以实现微通道中条纹声场的调制。在该装置中，芯片可一次性使用，换能器可重复使用。声全息图是通过注塑成型制造的，制造效率高，成本低。此外，还建立了全息声流体芯片的多物理场仿真模型，以分析声场调制和粒子操纵的影响。结果表明，该装置微通道内的声压呈现明显的条状分布，2 秒内可实现颗粒平行于通道壁延伸方向并倾斜于通道壁延伸方向的线性排列，目标区域的排列线间距控制在 60 μm 左右。对热效应的研究验证了其生物相容性。所设计的全息声学流体装置为在微通道中操纵、排列和分拣细胞及其他颗粒提供了一种很有前景的选择。

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来源期刊

Applied Acoustics 物理-声学

CiteScore

7.40

自引率

11.80%

发文量

618

审稿时长

7.5 months

期刊介绍： Since its launch in 1968, Applied Acoustics has been publishing high quality research papers providing state-of-the-art coverage of research findings for engineers and scientists involved in applications of acoustics in the widest sense. Applied Acoustics looks not only at recent developments in the understanding of acoustics but also at ways of exploiting that understanding. The Journal aims to encourage the exchange of practical experience through publication and in so doing creates a fund of technological information that can be used for solving related problems. The presentation of information in graphical or tabular form is especially encouraged. If a report of a mathematical development is a necessary part of a paper it is important to ensure that it is there only as an integral part of a practical solution to a problem and is supported by data. Applied Acoustics encourages the exchange of practical experience in the following ways: • Complete Papers • Short Technical Notes • Review Articles; and thereby provides a wealth of technological information that can be used to solve related problems. Manuscripts that address all fields of applications of acoustics ranging from medicine and NDT to the environment and buildings are welcome.