Microproteins unveiling new dimensions in cancer

IF 3.9 4区 生物学 Q1 GENETICS & HEREDITY Functional & Integrative Genomics Pub Date : 2024-09-03 DOI:10.1007/s10142-024-01426-8
S. Daisy Precilla, Indrani Biswas, T. S. Anitha, B. Agieshkumar
{"title":"Microproteins unveiling new dimensions in cancer","authors":"S. Daisy Precilla,&nbsp;Indrani Biswas,&nbsp;T. S. Anitha,&nbsp;B. Agieshkumar","doi":"10.1007/s10142-024-01426-8","DOIUrl":null,"url":null,"abstract":"<div><p>In the complex landscape of cancer biology, the discovery of microproteins has triggered a paradigm shift, thereby, challenging the conventional conceptions of gene regulation. Though overlooked for years, these entities encoded by the small open reading frames (100–150 codons), have a significant impact on various cellular processes. As precision medicine pioneers delve deeper into the genome and proteome, microproteins have come into the limelight. Typically characterized by a single protein domain that directly binds to the target protein complex and regulates their assembly, these microproteins have been shown to play a key role in fundamental biological processes such as RNA processing, DNA repair, and metabolism regulation. Techniques for identification and characterization, such as ribosome profiling and proteogenomic approaches, have unraveled unique mechanisms by which these microproteins regulate cell signaling or pathological processes in most diseases including cancer. However, the functional relevance of these microproteins in cancer remains unclear. In this context, the current review aims to “rethink the essence of these genes” and explore “how these hidden players-microproteins orchestrate the signaling cascades of cancer, both as accelerators and brakes.”.</p></div>","PeriodicalId":574,"journal":{"name":"Functional & Integrative Genomics","volume":"24 5","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Functional & Integrative Genomics","FirstCategoryId":"99","ListUrlMain":"https://link.springer.com/article/10.1007/s10142-024-01426-8","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0

Abstract

In the complex landscape of cancer biology, the discovery of microproteins has triggered a paradigm shift, thereby, challenging the conventional conceptions of gene regulation. Though overlooked for years, these entities encoded by the small open reading frames (100–150 codons), have a significant impact on various cellular processes. As precision medicine pioneers delve deeper into the genome and proteome, microproteins have come into the limelight. Typically characterized by a single protein domain that directly binds to the target protein complex and regulates their assembly, these microproteins have been shown to play a key role in fundamental biological processes such as RNA processing, DNA repair, and metabolism regulation. Techniques for identification and characterization, such as ribosome profiling and proteogenomic approaches, have unraveled unique mechanisms by which these microproteins regulate cell signaling or pathological processes in most diseases including cancer. However, the functional relevance of these microproteins in cancer remains unclear. In this context, the current review aims to “rethink the essence of these genes” and explore “how these hidden players-microproteins orchestrate the signaling cascades of cancer, both as accelerators and brakes.”.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
微蛋白揭示癌症新领域
在复杂的癌症生物学领域,微蛋白的发现引发了范式的转变,从而对基因调控的传统概念提出了挑战。虽然多年来一直被忽视,但这些由小的开放阅读框(100-150 个密码子)编码的实体对各种细胞过程有着重大影响。随着精准医疗先驱们对基因组和蛋白质组的深入研究,微小蛋白开始受到关注。这些微小蛋白的典型特征是具有单个蛋白结构域,可直接与目标蛋白复合物结合并调节其组装,它们已被证明在 RNA 处理、DNA 修复和新陈代谢调节等基本生物过程中发挥着关键作用。核糖体分析和蛋白质基因组学方法等鉴定和表征技术揭示了这些微蛋白调节细胞信号或包括癌症在内的大多数疾病的病理过程的独特机制。然而,这些微蛋白在癌症中的功能相关性仍不清楚。在此背景下,本综述旨在 "重新思考这些基因的本质",并探索 "这些隐藏的角色--微量蛋白如何协调癌症信号级联,既是加速器又是制动器"。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
3.50
自引率
3.40%
发文量
92
审稿时长
2 months
期刊介绍: Functional & Integrative Genomics is devoted to large-scale studies of genomes and their functions, including systems analyses of biological processes. The journal will provide the research community an integrated platform where researchers can share, review and discuss their findings on important biological questions that will ultimately enable us to answer the fundamental question: How do genomes work?
期刊最新文献
The role of disulfidptosis-associated LncRNA-LINC01137 in Osteosarcoma Biology and its regulatory effects on macrophage polarization Breaking the yield-quality tradeoff: OsNLP3 in rice Non-coding RNA notations, regulations and interactive resources Can nanotechnology and genomics innovations trigger agricultural revolution and sustainable development? Time-course RNA sequencing reveals high similarity in mRNAome between hepatic stellate cells activated by agalactosyl IgG and TGF-β1
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1