Application of Virtual Drug Study to New Drug Research and Development: Challenges and Opportunity.

IF 4.6 2区 医学 Q1 PHARMACOLOGY & PHARMACY Clinical Pharmacokinetics Pub Date : 2024-09-01 Epub Date: 2024-09-03 DOI:10.1007/s40262-024-01416-w
Xiuqi Li, Shupeng Liu, Dan Liu, Mengyang Yu, Xiaofei Wu, Hongyun Wang
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Abstract

In recent years, virtual drug study, as an emerging research strategy, has become increasingly important in guiding and promoting new drug research and development. Researchers can integrate a variety of technical methods to improve the efficiency of all phases of new drug research and development, including the use of artificial intelligence, modeling and simulation for target identification, compound screening and pharmacokinetic characteristics evaluation, and the application of clinical trial simulation to carry out clinical research. This paper aims to elaborate on the application of virtual drug study in the key stages of new drug research and development and discuss the opportunities and challenges it faces in supporting new drug research and development.

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虚拟药物研究在新药研发中的应用:挑战与机遇。
近年来,虚拟药物研究作为一种新兴的研究策略,在指导和推动新药研发方面发挥着越来越重要的作用。研究人员可以整合多种技术手段,提高新药研发各阶段的效率,包括利用人工智能、建模和仿真技术进行靶点识别、化合物筛选和药代动力学特征评价,以及应用临床试验模拟开展临床研究等。本文旨在阐述虚拟药物研究在新药研发关键阶段的应用,并探讨其在支持新药研发中面临的机遇和挑战。
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来源期刊
CiteScore
8.80
自引率
4.40%
发文量
86
审稿时长
6-12 weeks
期刊介绍: Clinical Pharmacokinetics promotes the continuing development of clinical pharmacokinetics and pharmacodynamics for the improvement of drug therapy, and for furthering postgraduate education in clinical pharmacology and therapeutics. Pharmacokinetics, the study of drug disposition in the body, is an integral part of drug development and rational use. Knowledge and application of pharmacokinetic principles leads to accelerated drug development, cost effective drug use and a reduced frequency of adverse effects and drug interactions.
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