Sheep and goats as reservoirs of colistin-resistant E. coli: first detection of ETEC ST10 and E. coli ST6396 mcr-1 positive strains in North Africa.

IF 3.2 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Journal of Applied Microbiology Pub Date : 2024-09-02 DOI:10.1093/jambio/lxae227

Fella Boukli-Hacene, Lydia Neïla Djouadi, Anis Raddaoui, Yousra Hachem, Hanane Boumerdassi, Wafa Achour, Farida Nateche

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Abstract

Aim: This study aimed to screen and characterize colistin-resistant strains isolated from different livestock species in Algeria, including sheep, goats, and dromedaries.

Methods and results: A total of 197 rectal and nasal swabs were screened for colistin-resistant Gram-negative bacilli. Twenty one isolates were selected, identified, and their antibiotic resistance was phenotypically and genotypically characterized. The majority (15/21) were affiliated to Escherichia coli, from which 4 strains isolated from sheep (n = 2) and goats (n = 2) and belonging to phylogroup A and ST10 and ST6396 lineages, respectively, carried the mcr-1 gene. The remaining isolates were identified as belonging to the following genera: Raoultella, Enterobacter, Klebsiella, and Pseudomonas.

Conclusion: This study highlights the presence of virulent and multiresistant Gram-negative bacilli in farm animals, increasing the risk of transmitting potentially fatal infections to humans.

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绵羊和山羊是耐大肠菌素大肠杆菌的储存库：首次在北非发现 ETEC ST10 和大肠杆菌 ST6396 mcr-1 阳性菌株。

目的：本研究旨在筛选和鉴定从阿尔及利亚不同牲畜物种（包括绵羊、山羊和单峰驼）中分离出的耐大肠杆菌素菌株：共对 197 份直肠和鼻拭子进行了耐药革兰氏阴性杆菌筛查。筛选、鉴定了 21 个分离株，并对其抗生素耐药性进行了表型和基因型鉴定。大部分（15/21）属于大肠杆菌，其中从绵羊（2 株）和山羊（2 株）分离出的 4 株分别属于 A 系统群、ST10 和 ST6396 系，携带 mcr-1 基因。其余分离物经鉴定属于以下菌属：结论：本研究强调了农场动物中存在毒性和多重耐药性革兰氏阴性杆菌，增加了向人类传播潜在致命感染的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Microbiology 生物-生物工程与应用微生物

CiteScore

7.30

自引率

2.50%

发文量

427

审稿时长

2.7 months

期刊介绍： Journal of & Letters in Applied Microbiology are two of the flagship research journals of the Society for Applied Microbiology (SfAM). For more than 75 years they have been publishing top quality research and reviews in the broad field of applied microbiology. The journals are provided to all SfAM members as well as having a global online readership totalling more than 500,000 downloads per year in more than 200 countries. Submitting authors can expect fast decision and publication times, averaging 33 days to first decision and 34 days from acceptance to online publication. There are no page charges.