The association between salivary pepsin and gastroesophageal reflux disease: A meta-analysis.

IF 3.5 3区医学 Q1 CLINICAL NEUROLOGY Neurogastroenterology and Motility Pub Date : 2024-11-01 Epub Date: 2024-09-02 DOI:10.1111/nmo.14905

Fei Han, Xiangyu Li, Zhaoxiang Song, Jinlin Xie, Nan Wang, Jianning Yao

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Abstract

Background and purpose: The definitive diagnosis of gastroesophageal reflux disease (GERD) often requires invasive investigations like upper gastrointestinal endoscopy or reflux monitoring. We aimed to explore the relationship between salivary pepsin and GERD and its value as a non-invasive diagnostic tool.

Methods: Databases (PubMed, Web of Science, Cochran Library, and EMBASE) were searched from their inception to January 22, 2024 to explore the correlation of salivary pepsin with GERD. The meta-analysis data retrieved were summarized, including the salivary pepsin concentration, sensitivity of diagnosis (SEN), specificity of diagnosis (SPE), negative likelihood ratio, positive likelihood ratio, diagnostic odds ratio, and receiver operating characteristic (ROC) curve.

Results: The meta-analysis comparing salivary pepsin concentration in two groups (proven GERD and non-GERD) with 18 studies revealed that the proven GERD group had higher salivary pepsin concentration than the non-GERD group (SMD = 1.74 [95% CI 1.14-2.34]). The meta-analysis of salivary pepsin diagnostic value for proven GERD incorporated 23 studies. The results showed pooled SEN (0.73 [95% CI 0.66-0.80]), SPE (0.72 [95% CI 0.65-0.78]), positive likelihood ratio (2.61 [95% CI 2.02-3.39]), negative likelihood ratio (0.37 [95% CI 0.28-0.50]), diagnostic odds ratio (7.03 [95% CI 4.24-11.66]) and area under the SROC curve (0.79 [95% CI 0.75-0.82]).

Conclusion: GERD patients presented a higher salivary pepsin concentration. Salivary pepsin is both sensitive and specific in identifying GERD, making it a promising non-invasive marker for diagnosis.

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唾液胃蛋白酶与胃食管反流病之间的关系：荟萃分析

背景和目的：胃食管反流病（GERD）的确诊通常需要上消化道内窥镜检查或反流监测等侵入性检查。我们旨在探讨唾液胃蛋白酶与胃食管反流病之间的关系及其作为非侵入性诊断工具的价值：方法：检索了从开始到 2024 年 1 月 22 日的数据库（PubMed、Web of Science、Cochran Library 和 EMBASE），以探讨唾液胃蛋白酶与胃食管反流病的相关性。对检索到的荟萃分析数据进行了总结，包括唾液胃蛋白酶浓度、诊断敏感性（SEN）、诊断特异性（SPE）、阴性似然比、阳性似然比、诊断几率和接收者操作特征曲线（ROC）：荟萃分析比较了两组（已证实胃食管反流病和非胃食管反流病）18 项研究的唾液胃蛋白酶浓度，结果显示，已证实胃食管反流病组的唾液胃蛋白酶浓度高于非胃食管反流病组（SMD = 1.74 [95% CI 1.14-2.34]）。唾液胃蛋白酶对已证实的胃食管反流病的诊断价值的荟萃分析纳入了 23 项研究。结果显示，汇总 SEN（0.73 [95% CI 0.66-0.80]）、SPE（0.72 [95% CI 0.65-0.78]）、阳性似然比（2.61 [95% CI 2.02-3.39]）、阴性似然比（0.37 [95% CI 0.28-0.50]）、诊断几率比（7.03 [95% CI 4.24-11.66]）和 SROC 曲线下面积（0.79 [95% CI 0.75-0.82]）：结论：胃食管反流病患者的唾液胃蛋白酶浓度较高。结论：胃食管反流病患者唾液胃蛋白酶浓度较高，唾液胃蛋白酶在识别胃食管反流病方面具有敏感性和特异性，是一种很有前途的非侵入性诊断标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurogastroenterology and Motility 医学-临床神经学

CiteScore

7.80

自引率

8.60%

发文量

178

审稿时长

3-6 weeks

期刊介绍： Neurogastroenterology & Motility (NMO) is the official Journal of the European Society of Neurogastroenterology & Motility (ESNM) and the American Neurogastroenterology and Motility Society (ANMS). It is edited by James Galligan, Albert Bredenoord, and Stephen Vanner. The editorial and peer review process is independent of the societies affiliated to the journal and publisher: Neither the ANMS, the ESNM or the Publisher have editorial decision-making power. Whenever these are relevant to the content being considered or published, the editors, journal management committee and editorial board declare their interests and affiliations.