cGAS/STING signalling pathway in senescence and oncogenesis

IF 12.1 1区 医学 Q1 ONCOLOGY Seminars in cancer biology Pub Date : 2024-08-31 DOI:10.1016/j.semcancer.2024.08.007
Le Yu , Pengda Liu
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Abstract

The cGAS/STING signaling pathway is a crucial component of the innate immune system, playing significant roles in sensing cytosolic DNA, regulating cellular senescence, and contributing to oncogenesis. Recent advances have shed new lights into the molecular mechanisms governing pathway activation in multiple pathophysiological settings, the indispensable roles of cGAS/STING signaling in cellular senescence, and its context-dependent roles in cancer development and suppression. This review summarizes current knowledge related to the biology of cGAS/STING signaling pathway and its participations into senescence and oncogenesis. We further explore the clinical implications and therapeutic potential for cGAS/STING targeted therapies, and faced challenges in the field. With a focus on molecular mechanisms and emerging pharmacological targets, this review underscores the importance of future studies to harness the therapeutic potential of the cGAS/STING pathway in treating senescence-related disorders and cancer. Advanced understanding of the regulatory mechanisms of cGAS/STING signaling, along with the associated deregulations in diseases, combined with the development of new classes of cGAS/STING modulators, hold great promises for creating novel and effective therapeutic strategies. These advancements could address current treatment challenges and unlock the full potential of cGAS/STING in treating senescence-related disorders and oncogenesis.

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cGAS/STING 信号通路在衰老和肿瘤发生中的作用。
cGAS/STING 信号通路是先天性免疫系统的重要组成部分,在感知细胞膜 DNA、调节细胞衰老和促进肿瘤发生方面发挥着重要作用。最近的研究进展揭示了在多种病理生理环境下激活该通路的分子机制、cGAS/STING 信号在细胞衰老中不可或缺的作用,以及它在癌症发展和抑制中的环境依赖性作用。本综述总结了当前与 cGAS/STING 信号通路生物学及其参与衰老和致癌相关的知识。我们进一步探讨了 cGAS/STING 靶向疗法的临床意义和治疗潜力,以及该领域面临的挑战。本综述以分子机制和新兴药理靶点为重点,强调了未来研究利用 cGAS/STING 通路的治疗潜力治疗衰老相关疾病和癌症的重要性。深入了解 cGAS/STING 信号传导的调控机制以及疾病中的相关失调,再加上开发新型 cGAS/STING 调节剂,有望创造出新型有效的治疗策略。这些进展可以解决目前的治疗难题,并释放 cGAS/STING 在治疗衰老相关疾病和肿瘤发生方面的全部潜力。
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来源期刊
Seminars in cancer biology
Seminars in cancer biology 医学-肿瘤学
CiteScore
26.80
自引率
4.10%
发文量
347
审稿时长
15.1 weeks
期刊介绍: Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.
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