Unravelling the Causal Relationship between Endometriosis and the Risk for Developing Venous Thromboembolism: A Pooled Analysis.

IF 5 2区 医学 Q1 HEMATOLOGY Thrombosis and haemostasis Pub Date : 2024-09-18 DOI:10.1055/a-2407-9498
Pauline De Corte, Igor Milhoranca, Sylvia Mechsner, Anna Sara Oberg, Tobias Kurth, Klaas Heinemann
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Abstract

Objective:  To investigate the effect of endometriosis on venous thromboembolism (VTE) in oral contraceptive (OC) users. Pooled analysis on a harmonized dataset compromising international patient-centric cohort studies: INAS-VIPOS, INAS-SCORE, and INAS-FOCUS. Eleven European countries, the United States, and Canada. Individuals being newly prescribed an OC with or without an endometriosis and no VTE history.

Methods:  Detailed information was captured using self-administered questionnaires at baseline and every 6 to 12 months thereafter. Self-reported VTEs were medically validated and reviewed by an independent adjudication committee. Incidence rates (IRs) were calculated per 10,000 woman-years. The association of endometriosis on VTE was determined in a time-to-event analysis, calculating crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) using stabilized inverse probability of treatment weighting (IPTW).

Results:  A total of 22,072 women had an endometriosis diagnosis, and 91,056 women did not. Women with endometriosis contributed 78,751 woman-years during which 41 VTE events occurred (IR: 5.2/10,000, 95% CI: 3.7-7.1) compared to 127 VTEs during 310,501 woman-years in women without endometriosis (IR: 4.1/10,000, 95% CI: 3.4-4.9). The hazard ratio of VTE in women with endometriosis was 1.79 (95% CI: 1.24-2.57) using stabilized IPTW controlling for age, body mass index, smoking, education, age at menarche, and family history of VTE. Subgroup and sensitivity analyses showed similar results.

Conclusion:  These results highlight the importance of considering endometriosis as a potential factor contributing to VTE in women using OC; however, further research on the relationship between endometriosis and VTE is warranted.

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揭示子宫内膜异位症与静脉血栓栓塞风险之间的因果关系:汇总分析。
目的研究子宫内膜异位症对口服避孕药(OCs)使用者静脉血栓栓塞症(VTE)的影响:对以患者为中心的国际队列研究的统一数据集进行汇总分析:背景:11 个欧洲国家、美国和加拿大:11 个欧洲国家、美国和加拿大 人口:环境:11 个欧洲国家、美国和加拿大。方法:通过自我问卷调查获取详细信息:方法:在基线期及之后每 6-12 个月使用自填问卷收集详细信息。自我报告的 VTE 经过医学验证,并由独立评审委员会进行审查。发病率(IR)按每万名妇女年计算。子宫内膜异位症与 VTE 的关系通过时间到事件分析来确定,使用稳定的逆治疗概率加权法(IPTW)计算粗略和调整后的危险比(HRs)及 95% 置信区间(CI):共有 22,072 名妇女确诊患有子宫内膜异位症,91,056 名妇女未确诊。患有子宫内膜异位症的妇女在 78,751 个妇女年中发生了 41 次 VTE 事件(IR:5.2/10,000,95% CI:3.7-7.1),而未患有子宫内膜异位症的妇女在 310,501 个妇女年中发生了 127 次 VTE 事件(IR:4.1/10,000,95% CI:3.4-4.9)。在控制了年龄、体重指数(BMI)、吸烟、教育程度、初潮年龄和 VTE 家族史后,子宫内膜异位症妇女发生 VTE 的 HR 为 1.79(95% CI:1.24-2.57)。分组分析和敏感性分析显示了相似的结果:这些结果凸显了将子宫内膜异位症视为导致使用OC的女性出现VTE的潜在因素的重要性,但还需要进一步研究子宫内膜异位症与VTE之间的关系:关键词子宫内膜异位症 静脉血栓栓塞。
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来源期刊
Thrombosis and haemostasis
Thrombosis and haemostasis 医学-外周血管病
CiteScore
11.90
自引率
9.00%
发文量
140
审稿时长
1 months
期刊介绍: Thrombosis and Haemostasis publishes reports on basic, translational and clinical research dedicated to novel results and highest quality in any area of thrombosis and haemostasis, vascular biology and medicine, inflammation and infection, platelet and leukocyte biology, from genetic, molecular & cellular studies, diagnostic, therapeutic & preventative studies to high-level translational and clinical research. The journal provides position and guideline papers, state-of-the-art papers, expert analysis and commentaries, and dedicated theme issues covering recent developments and key topics in the field.
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