Is cardiac function associated with the clinical course of disease in patients with gout? A prospective study

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2024-09-03 DOI:10.1111/echo.15911

Yanni Dong MD, Yiming Li MD, Caijie Liu MD, Yingnan Guo MD, Yanhong Feng MD, PhD

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Abstract

Objective

To analyze the function of the left heart in patients with different courses of gout, the independent influencing factors for left heart functional changes, and interactions between left atrial and left ventricular functions.

Methods

Patients with gout (n = 171) were selected; 87 patients with a disease course <10 years were included in Group I, and 84 patients with a disease course ≥10 years were included in Group II. Ninety-four healthy volunteers comprised the control group.

Results

The intergroup differences in cardiac strain parameters were statistically significant (p < .05). Moreover, the differences gradually declined with disease progression. Multivariate logistic regression analysis showed that uric acid was an independent predictor of decreased left ventricular global longitudinal strain (LVGLS). Moreover, LVGLS had a positive effect on the left atrial systolic rate (LASr) and the left atrial systolic contraction time (LASct) but no interaction with the left atrial systolic contraction duration (LAScd).

Conclusion

The course of the disease significantly affected the function of the left heart in gout patients, and uric acid was observed to be an independent predictor of decreased LVGLS in gout patients.

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心脏功能与痛风患者的临床病程有关吗？一项前瞻性研究。

目的分析不同病程痛风患者的左心功能、左心功能变化的独立影响因素以及左心房和左心室功能之间的相互作用：方法：选取痛风患者（n = 171），其中87例为病程结果：心脏应变参数的组间差异具有统计学意义（P病程对痛风患者的左心功能有明显影响，观察发现尿酸是痛风患者左心室GLS下降的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.

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