Levels of plasma 25-hydroxy vitamin D and risk of developing type 2 diabetes in a large Danish primary health care population.

IF 3.1 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Acta Diabetologica Pub Date : 2024-09-03 DOI:10.1007/s00592-024-02368-0

Cecilie Korneliusen Rohold, Henrik Løvendahl Jørgensen, Fie Juhl Vojdeman, Christian Medom Madsen, Anja Olsen, Anne-Marie Heegaard, Bent Struer Lind, Anne Tjønneland, Peter Schwarz, Peter Haulund Gæde

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Abstract

Aims: Plasma levels of Vitamin D (25(OH)D) have been suggested as a predictor for developing type 2 diabetes. The purpose of this study was therefore to investigate if a measurement of plasma 25(OH)D could predict the development of type 2 diabetes in a cohort of 222,311 individuals from primary healthcare in Denmark.

Methods: The CopD-study database containing data from the Copenhagen General Practitioners Laboratory on blood tests conducted from April 2004 to January 2012 was used for identification of the study population. Incident type 2 diabetes was then defined as having at least two redeemed prescriptions of antidiabetics or at least two hospital contacts due to type 2 diabetes or one redeemed prescription and one hospital contact regarding type 2 diabetes.

Results: A total of 222,311 individuals were included in the study, of whom 7652 (3.4%) developed type 2 diabetes during the follow-up period of minimum one year. Individuals who developed type 2 diabetes had a significantly lower median 25(OH)D level than persons in the non-diabetes group. The hazard ratio for development of type 2 diabetes increased by 15% per 10 n mol/L decrease in 25(OH)D level.

Conclusion: In this study of 222,311 persons from primary health care in Denmark, we found a clear inverse relationship between 25(OH)D and the risk of developing type 2 diabetes. Further studies should be conducted to clarify the mechanisms behind the relationship between 25(OH)D and type 2 diabetes and the effect of oral vitamin D supplementation on the development of type 2 diabetes.

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丹麦大型基层医疗机构人群中血浆 25- 羟基维生素 D 的水平与罹患 2 型糖尿病的风险。

目的：血浆维生素 D (25(OH)D) 水平被认为是预测 2 型糖尿病发病的一个指标。因此，本研究旨在调查血浆 25(OH)D 测量值是否能预测丹麦 222,311 名初级医疗保健人员中 2 型糖尿病的发病情况：CopD研究数据库包含哥本哈根全科医师实验室2004年4月至2012年1月期间的血液检测数据，用于确定研究人群。2型糖尿病的定义是：至少有两个抗糖尿病药物处方被兑换，或至少有两次因2型糖尿病而到医院就诊，或有一个处方被兑换和一次因2型糖尿病而到医院就诊：研究共纳入 222311 人，其中 7652 人（3.4%）在至少一年的随访期间罹患 2 型糖尿病。与非糖尿病组相比，2型糖尿病患者的25（OH）D水平中位数明显偏低。25（OH）D水平每下降10 n mol/L，2型糖尿病发病的危险比增加15%：在这项针对丹麦 222,311 名初级医疗保健人员的研究中，我们发现 25（OH）D 与 2 型糖尿病发病风险之间存在明显的反比关系。应开展进一步研究，以明确 25（OH）D 与 2 型糖尿病之间关系背后的机制，以及口服维生素 D 补充剂对 2 型糖尿病发病的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Diabetologica 医学-内分泌学与代谢

CiteScore

7.30

自引率

2.60%

发文量

180

审稿时长

2 months

期刊介绍： Acta Diabetologica is a journal that publishes reports of experimental and clinical research on diabetes mellitus and related metabolic diseases. Original contributions on biochemical, physiological, pathophysiological and clinical aspects of research on diabetes and metabolic diseases are welcome. Reports are published in the form of original articles, short communications and letters to the editor. Invited reviews and editorials are also published. A Methodology forum, which publishes contributions on methodological aspects of diabetes in vivo and in vitro, is also available. The Editor-in-chief will be pleased to consider articles describing new techniques (e.g., new transplantation methods, metabolic models), of innovative importance in the field of diabetes/metabolism. Finally, workshop reports are also welcome in Acta Diabetologica.