Efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in anejaculation: A randomized controlled trial.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-09-04 DOI:10.1111/andr.13752

Ming Wang, Qiushi Liu, Hui Gao, Dangwei Peng, Weinan Wang, Juncheng Ma, Zihang Chen, Wangheng Zhang, Tommaso B Jannini, Emmanuele A Jannini, Hui Jiang, Xiansheng Zhang

{"title":"Efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) in anejaculation: A randomized controlled trial.","authors":"Ming Wang, Qiushi Liu, Hui Gao, Dangwei Peng, Weinan Wang, Juncheng Ma, Zihang Chen, Wangheng Zhang, Tommaso B Jannini, Emmanuele A Jannini, Hui Jiang, Xiansheng Zhang","doi":"10.1111/andr.13752","DOIUrl":null,"url":null,"abstract":"Background: Anejaculation represents significant psychological distress and sexual and reproductive challenges among male individuals and couples. Effective fertility management options are available to address the reproductive challenges associated with anejaculation. However, there is a lack of methods to reverse the condition itself.Objectives: This study aims to assess the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in patients suffering from anejaculation.Methods: A total of 94 patients with anejaculation individuals were randomly assigned to receive high-frequency (HF) stimulation on the left dorsolateral prefrontal cortex (DLPFC), low-frequency (LF) stimulation on the right DLPFC, and sham stimulation for 4 weeks, with daily sessions of stimulation occurring on five consecutive weekdays each week.Results: After 4 weeks of rTMS treatment, the patients in both the HF and LF groups exhibited a similar reduction in their male sexual health questionnaire for ejaculatory dysfunction bother/satisfaction score, Hamilton Anxiety Scale score, Hamilton Depression Scale score, and Pittsburgh Sleep Quality Inventory score, which were statistically significant compared with sham treatment. Additionally, there were no significant differences observed in erectile function and cognitive function across the three groups. However, there were notable disparities in the cure rates between HF- and LF-group patients (16.1% vs. 54.8%, p = 0.001). Additionally, it is worth noting that only two HF group patients and one LF group patient experienced spontaneously resolving minor adverse effects during the treatment process. At the 8-week follow-up, among patients who initially responded to the treatment, only one from the HF group experienced a relapse.Discussion and conclusion: The findings of this study demonstrate that rTMS represents a secure and efficacious remedy for anejaculation patients.","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/andr.13752","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Anejaculation represents significant psychological distress and sexual and reproductive challenges among male individuals and couples. Effective fertility management options are available to address the reproductive challenges associated with anejaculation. However, there is a lack of methods to reverse the condition itself.

Objectives: This study aims to assess the effectiveness and safety of repetitive transcranial magnetic stimulation (rTMS) in patients suffering from anejaculation.

Methods: A total of 94 patients with anejaculation individuals were randomly assigned to receive high-frequency (HF) stimulation on the left dorsolateral prefrontal cortex (DLPFC), low-frequency (LF) stimulation on the right DLPFC, and sham stimulation for 4 weeks, with daily sessions of stimulation occurring on five consecutive weekdays each week.

Results: After 4 weeks of rTMS treatment, the patients in both the HF and LF groups exhibited a similar reduction in their male sexual health questionnaire for ejaculatory dysfunction bother/satisfaction score, Hamilton Anxiety Scale score, Hamilton Depression Scale score, and Pittsburgh Sleep Quality Inventory score, which were statistically significant compared with sham treatment. Additionally, there were no significant differences observed in erectile function and cognitive function across the three groups. However, there were notable disparities in the cure rates between HF- and LF-group patients (16.1% vs. 54.8%, p = 0.001). Additionally, it is worth noting that only two HF group patients and one LF group patient experienced spontaneously resolving minor adverse effects during the treatment process. At the 8-week follow-up, among patients who initially responded to the treatment, only one from the HF group experienced a relapse.

Discussion and conclusion: The findings of this study demonstrate that rTMS represents a secure and efficacious remedy for anejaculation patients.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

重复经颅磁刺激（rTMS）对无射精症的疗效和安全性：随机对照试验。

背景：在男性个体和夫妇中，遗精代表着严重的心理困扰以及性和生殖方面的挑战。目前已有有效的生育管理方案来应对与遗精相关的生殖挑战。然而，目前还缺乏扭转这种情况的方法：本研究旨在评估重复经颅磁刺激（rTMS）对无射精症患者的有效性和安全性：共有94名射精障碍患者被随机分配接受左侧背外侧前额叶皮层（DLPFC）的高频（HF）刺激、右侧DLPFC的低频（LF）刺激和假刺激，为期4周，每周连续5个工作日进行每日刺激：经颅磁刺激治疗4周后，高频组和低频组患者的男性性健康问卷中射精功能障碍困扰/满意度评分、汉密尔顿焦虑量表评分、汉密尔顿抑郁量表评分和匹兹堡睡眠质量量表评分均有类似程度的下降，与假治疗相比具有统计学意义。此外，在勃起功能和认知功能方面，三组之间没有观察到明显差异。不过，高频组和低频组患者的治愈率存在明显差异（16.1% 对 54.8%，P = 0.001）。此外，值得注意的是，只有两名高频组患者和一名低频组患者在治疗过程中出现了自发缓解的轻微不良反应。在 8 周的随访中，最初对治疗有反应的高频组患者中只有一人复发：本研究结果表明，经颅磁刺激是治疗不射精症患者的一种安全有效的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊