Omeprazole affects the expression of serotonin-1A in the brain regions and alleviates anxiety in rat model of immobilization-induced stress.

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2024-10-01 Epub Date: 2024-09-03 DOI:10.1097/FBP.0000000000000793

Sadia Basharat Ali, Raheel Saeed, Khalid Mahmood, Darakhshan Jabeen Haleem

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Abstract

Omeprazole, a drug of choice for the management of gastric hyperacidity, influences serotonergic neurotransmission in brain regions and its long-term use is known to cause stress-related behavioral deficits including anxiety. Aim of the current study was to explore the effects of omeprazole treatment on immobilization-induced anxiety in rats, specifically on the role of serotonin (5-HT). In view of the role of serotonin-1A (5-HT1A) autoreceptor in the availability of 5-HT in brain regions, mRNA expression of this autoreceptor was performed in raphe nuclei. Similarly, because of the role of hippocampal 5-HT neurotransmission in anxiety-like disorders, expression of the 5-HT1A heteroreceptors was determined in this region. We found that the treatment with omeprazole reduces anxiety-like behavior in rats, increases the expression of 5-HT1A autoreceptor in the raphe and decreases the hippocampal expression of 5-HT1A heteroreceptor. This suggests a role of 5-HT1A receptor types in omeprazole-induced behavioral changes. It also indicates a potential role of omeprazole in the management of serotonergic disorders.

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奥美拉唑影响脑区血清素-1A的表达，缓解固定诱导应激模型大鼠的焦虑。

奥美拉唑是治疗胃酸过多的首选药物，它会影响脑区的血清素能神经递质，长期使用奥美拉唑会导致包括焦虑在内的应激相关行为障碍。本研究旨在探讨奥美拉唑治疗对大鼠固定诱发焦虑的影响，特别是对血清素（5-HT）作用的影响。鉴于5-羟色胺-1A（5-HT1A）自身受体在脑区5-羟色胺的可用性中的作用，研究人员对该自身受体的mRNA表达进行了研究。同样，由于海马5-HT神经传导在焦虑症中的作用，我们还测定了该区域5-HT1A异体受体的表达。我们发现，用奥美拉唑治疗可减少大鼠的焦虑样行为，增加剑突中 5-HT1A 自体受体的表达，减少海马中 5-HT1A 异体受体的表达。这表明 5-HT1A 受体类型在奥美拉唑诱导的行为变化中发挥作用。这也表明奥美拉唑在治疗血清素能紊乱中的潜在作用。

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.