Effectiveness and safety of acupuncture as an adjunctive therapy for chronic obstructive pulmonary disease: a randomised controlled trial.

IF 3.3 2区 医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE BMC Complementary Medicine and Therapies Pub Date : 2024-09-03 DOI:10.1186/s12906-024-04630-y
Guixing Xu, Qin Luo, Mingsheng Sun, Liuyang Huang, Jiali Liu, Chunyan Yang, Qingsong Huang, Chan Xiong, Zuoqin Yang, Sha Yang, Fang Zeng, Fanrong Liang
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Abstract

Background: The effectiveness and safety of acupuncture therapy to delay lung function decline in chronic obstructive pulmonary disease (COPD) remain unclear. This study aimed to determine whether acupuncture, as an adjunctive therapy to COPD-guided medication, could prevent lung function decline.

Methods: This randomised, two-centre study was conducted between February 2022 and July 2023. Men and women aged 40-80 years with COPD were recruited. Participants received active or sham acupuncture three times a week (36 sessions total). The primary outcome was the change in the percentage of forced expiratory volume for 1 s to the predicted value (FEV1%) between the baseline and after the intervention.

Results: Overall, 238 participants were screened, and 74 (58 men [78.4%]; mean [standard deviation] age, 69.6 [7.2] years) were randomised into the acupuncture and sham acupuncture groups (37 per group). After the intervention, the change in FEV1% was 1.35 (95% confidence interval [CI]: -0.47 to 3.17) and -2.44 (95% CI: -4.56 to -0.33) in the acupuncture and sham acupuncture groups, respectively. The difference was -3.97 (95% CI: -6.2 to -1.74), and the adjusted difference was -3.46 (95% CI: -5.69 to -1.24, P = 0.003) between the groups. A significantly less decline was found in forced expiratory volume for 1 s in the acupuncture group. All treatment-related adverse events (acupuncture = 11, sham = 2) were mild.

Conclusions: Compared with sham acupuncture, acupuncture plus medication may delay lung function decline. However, further studies with a larger sample size and longer-term follow-up are needed to clarify the effects.

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针灸作为慢性阻塞性肺病辅助疗法的有效性和安全性:随机对照试验。
背景:针灸疗法延缓慢性阻塞性肺疾病(COPD)患者肺功能下降的有效性和安全性仍不明确。本研究旨在确定针灸作为慢性阻塞性肺疾病药物治疗的辅助疗法,能否预防肺功能下降:这项随机双中心研究于 2022 年 2 月至 2023 年 7 月间进行。研究招募了 40-80 岁的男性和女性慢性阻塞性肺病患者。参与者每周接受三次主动或假针灸(共 36 次)。主要结果是干预后1秒用力呼气量占预测值的百分比(FEV1%)在基线和干预后的变化:共筛选出 238 名参与者,其中 74 人(58 名男性 [78.4%];平均 [标准差] 年龄 69.6 [7.2] 岁)被随机分为针灸组和假针灸组(每组 37 人)。干预后,针灸组和假针灸组的 FEV1% 变化分别为 1.35(95% 置信区间 [CI]:-0.47 至 3.17)和 -2.44(95% CI:-4.56 至 -0.33)。两组之间的差异为-3.97(95% CI:-6.2 至-1.74),调整后的差异为-3.46(95% CI:-5.69 至-1.24,P = 0.003)。针灸组 1 秒用力呼气量的下降幅度明显较小。所有与治疗相关的不良反应(针灸 = 11,假针灸 = 2)均为轻微:结论:与假针灸相比,针灸加药物治疗可延缓肺功能下降。结论:与假针灸相比,针灸加药物治疗可延缓肺功能下降,但还需要更多样本量和更长期随访的进一步研究来明确其效果。
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来源期刊
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
6.10
自引率
2.60%
发文量
300
审稿时长
19 weeks
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