Inflammatory response to SARS-CoV 2 and other respiratory viruses.

IF 4.2 2区 医学 Q1 INFECTIOUS DISEASES Expert Review of Anti-infective Therapy Pub Date : 2024-09-11 DOI:10.1080/14787210.2024.2400548
André Emilio Viñán Garcés, Eder Cáceres, Juan Olivella Gómez, Ignacio Martín-Loeches, Luis Felipe Reyes
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Abstract

Introduction: Lower respiratory tract infections (LRTI) remain a significant global cause of mortality and disability. Viruses constitute a substantial proportion of LRTI cases, with their pandemic potential posing a latent threat. After the SARS-CoV-2 pandemic, the resurgence of other respiratory viruses, including Influenza and Respiratory Syncytial Virus responsible for LRTI has been observed especially in susceptible populations.

Areas covered: This review details the inflammatory mechanisms associated with three primary respiratory viruses: SARS-CoV-2, Influenza, and Respiratory Syncytial Virus (RSV). The focus will be on elucidating the activation of inflammatory pathways, understanding cellular contributions to inflammation, exploring the role of interferon and induced cell death in the response to these pathogens and detailing viral evasion mechanisms. Furthermore, the distinctive characteristics of each virus will be explained.

Expert opinion: The study of viral pneumonia, notably concerning SARS-CoV-2, Influenza, and RSV, offers critical insights into infectious and inflammatory mechanisms with wide-ranging implications. Addressing current limitations, such as diagnostic accuracy and understanding host-virus interactions, requires collaborative efforts and investment in technology. Future research holds promise for uncovering novel therapeutic targets, exploring host microbiome roles, and addressing long-term sequelae. Integrating advances in molecular biology and technology will shape the evolving landscape of viral pneumonia research, potentially enhancing global public health outcomes.

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sars-CoV 2 和其他呼吸道病毒的炎症反应。
导言:下呼吸道感染(LRTI)仍然是导致全球死亡和残疾的一个重要原因。病毒在下呼吸道感染病例中占很大比例,其大流行的潜力构成了潜在威胁。在 SARS-CoV-2 大流行之后,其他呼吸道病毒,包括导致 LRTI 的流感病毒和呼吸道合胞病毒再次出现,尤其是在易感人群中:本综述详细介绍了与三种主要呼吸道病毒相关的炎症机制:本综述详细介绍了与三种主要呼吸道病毒(SARS-CoV-2、流感和呼吸道合胞病毒 (RSV))相关的炎症机制。重点将放在阐明炎症途径的激活、了解细胞对炎症的贡献、探索干扰素和诱导细胞死亡在对这些病原体的反应中的作用以及详细介绍病毒的逃避机制。此外,还将解释每种病毒的独特特征:病毒性肺炎的研究,特别是有关 SARS-CoV-2、流感和 RSV 的研究,为我们提供了有关感染和炎症机制的重要见解,具有广泛的影响。要解决目前存在的局限性,如诊断准确性和了解宿主与病毒之间的相互作用,需要各方的共同努力和技术投资。未来的研究有望发现新的治疗靶点,探索宿主微生物组的作用,并解决长期后遗症问题。整合分子生物学和技术的进步将塑造病毒性肺炎研究不断发展的格局,并有可能提高全球公共卫生成果。
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来源期刊
CiteScore
11.20
自引率
0.00%
发文量
66
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anti-Infective Therapy (ISSN 1478-7210) provides expert reviews on therapeutics and diagnostics in the treatment of infectious disease. Coverage includes antibiotics, drug resistance, drug therapy, infectious disease medicine, antibacterial, antimicrobial, antifungal and antiviral approaches, and diagnostic tests.
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