PBMC-engrafted humanized mice models for evaluating immune-related and anticancer drug delivery systems.

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Frontiers in Molecular Biosciences Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI:10.3389/fmolb.2024.1447315

Yoshie Kametani, Ryoji Ito, Yoshiyuki Manabe, Jerzy K Kulski, Toshiro Seki, Hitoshi Ishimoto, Takashi Shiina

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Abstract

Immune-related drug delivery systems (DDSs) in humanized mouse models are at the forefront of cancer research and serve as bridges between preclinical studies and clinical applications. These systems offer unique platforms for exploring new therapies and understanding their interactions with human cells and the immune system. Here, we focus on a DDS and a peripheral blood mononuclear cell (PBMC)-engrafted humanized mouse model that we recently developed, and consider some of the key components, challenges, and applications to advance these systems towards better cancer treatment on the basis of a better understanding of the immune response. Our DDS is unique and has a dual function, an anticancer effect and a capacity to fine-tune the immune reaction. The PBL-NOG-hIL-4-Tg mouse system is superior to other available humanized mouse systems for the development of such multifunctional DDSs because it supports the rapid reconstruction of an individual donor's immunity and avoids the onset of graft-versus-host disease.

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用于评估免疫相关给药系统和抗癌给药系统的 PBMC 接种人源化小鼠模型。

人源化小鼠模型中的免疫相关给药系统（DDS）处于癌症研究的前沿，是临床前研究与临床应用之间的桥梁。这些系统为探索新疗法和了解它们与人体细胞和免疫系统的相互作用提供了独特的平台。在这里，我们将重点介绍我们最近开发的 DDS 和外周血单核细胞（PBMC）移植人源化小鼠模型，并考虑一些关键组成部分、挑战和应用，以便在更好地了解免疫反应的基础上推动这些系统更好地治疗癌症。我们的 DDS 具有独特的双重功能：抗癌效果和免疫反应微调能力。PBL-NOG-hIL-4-Tg小鼠系统在开发这种多功能DDS方面优于其他现有的人源化小鼠系统，因为它支持供体个体免疫力的快速重建，避免了移植物抗宿主疾病的发生。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.