HER2 Status in Low-grade Serous Ovarian Tumors.

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Pathology Pub Date : 2024-07-30 DOI:10.1097/PGP.0000000000001059
Kristýna Němejcová, Adam Šafanda, Michaela Kendall Bártů, Nikola Hájková, Jana Drozenová, Pavel Fabian, Jan Laco, Radoslav Matěj, Gábor Méhes, Petr Škapa, Ivana Stružinská, Pavel Dundr
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Abstract

Using immunohistochemistry, we examined a large cohort of 135 ovarian tumors, made up of 96 low-grade serous carcinomas (LGSCs) and 39 serous borderline tumors (micropapillary variant, mSBT), with the aim of exploring their HER2 status (overexpression). We followed with comprehensive genomic analyses on this sample set from our previous study, which revealed HER2 mutation in 5% (4/75) of LGSC and 10% (3/29) of mSBT. No cases were evaluated as HER2-positive, but 6 LGSCs and 1 mSBT were scored as HER2 1+, and 2 LGSCs and 1 mSBT showed the so-called HER2 "ultra-low" phenotype. This could be of clinical value as a potential therapeutical target concerning emerging therapeutic treatments (antibody conjugates). However, the clinical significance of this expression still needs to be established.

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低级别浆液性卵巢肿瘤的 HER2 状态
我们使用免疫组化方法检查了一大批 135 例卵巢肿瘤,其中包括 96 例低级别浆液性癌(LGSCs)和 39 例浆液性边界肿瘤(微乳头状变异,mSBT),目的是探索它们的 HER2 状态(过表达)。我们随后对之前研究中的这组样本进行了全面的基因组分析,结果发现5%的LGSC(4/75)和10%的mSBT(3/29)存在HER2突变。没有病例被评估为HER2阳性,但有6例LGSCs和1例mSBT被评为HER2 1+,2例LGSCs和1例mSBT显示出所谓的HER2 "超低 "表型。这可能具有临床价值,因为它是新出现的治疗方法(抗体共轭物)的潜在治疗靶点。然而,这种表达的临床意义仍有待确定。
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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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