{"title":"Synthesis of pyrrolo[1,2-a]quinoline and pyrrolo[1,2-b]isoquinoline derivatives via intramolecular acylation","authors":"","doi":"10.1016/j.tet.2024.134224","DOIUrl":null,"url":null,"abstract":"<div><p>A methanesulfonic acid mediated intramolecular acylation approach for the synthesis of pyrrolo[1,2-<em>a</em>]quinoline and the isomeric pyrrolo[1,2-<em>b</em>]isoquinoline frameworks has been developed. The reaction is carried out at ambient temperature and no Lewis acid catalyst is required. The product yields are generally good to excellent.</p></div>","PeriodicalId":437,"journal":{"name":"Tetrahedron","volume":null,"pages":null},"PeriodicalIF":2.1000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040402024004046","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
A methanesulfonic acid mediated intramolecular acylation approach for the synthesis of pyrrolo[1,2-a]quinoline and the isomeric pyrrolo[1,2-b]isoquinoline frameworks has been developed. The reaction is carried out at ambient temperature and no Lewis acid catalyst is required. The product yields are generally good to excellent.
期刊介绍：
Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry.
Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters.
Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.
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