Association between insulin-like growth factor-1 and ocular surface parameters in obese prepubertal boys.

IF 3 3区医学 Q1 PEDIATRICS European Journal of Pediatrics Pub Date : 2024-11-01 Epub Date: 2024-09-05 DOI:10.1007/s00431-024-05748-4

Wen Jiang, Lixia Yang, Shuang Liang

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Abstract

The study aimed to investigate the correlation between insulin-like growth factor 1 (IGF-1) and ocular surface parameters in obese prepubertal boys. Thirty obese prepubertal boys and 30 age- and gender-matched healthy controls underwent physical measurements, laboratory tests, and ocular surface assessments. The obese group showed lower IGF-1 levels (P = 0.001), reduced Schirmer I tear test (SIT) (P <0.001), and higher meibomian gland scores (meiboscore) compared to controls (P = 0.015). Bivariate analysis revealed a positive association between IGF-1 and SIT (r = 0.677, P < 0.001), and a negative association with between IGF-1 and meiboscore (r = - 0.487, P < 0.001). Multiple regression analysis indicated that IGF-1 (P < 0.001) and triglycerides (P = 0.028) independently influenced SIT. Logistic analysis showed a significant association between decreased IGF-1 and higher meiboscore values (OR 0.994, 95% confidence interval 0.988-1.000; P = 0.033).

Conclusion: The findings suggest that reduced IGF-1 in obese prepubertal boys is independently linked to decreased SIT and increased meiboscore, irrespective of obesity and traditional cardiovascular risk factors. This implies that monitoring ocular surface parameters in obese children might provide a new perspective for clinical practice to focus on.

What is known: • Obese children exhibit decreased levels of IGF-1, and this reduction in IGF-1 is associated with cardiovascular metabolic complications related to obesity. • Ocular surface tissues might act as targets for hormones, might experience local effects of these hormone.

What is new: • In prepubertal obese boys, the decrease in IGF-1 is independently linked to decreased SIT and increased meiboscore, irrespective of obesity and traditional cardiovascular risk factors. • This finding implies that monitoring ocular surface parameters in obese children might provide a new perspective for clinical practice to focus on.

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肥胖青春期前男孩的胰岛素样生长因子-1与眼表参数之间的关系。

该研究旨在调查肥胖青春期前男孩的胰岛素样生长因子1（IGF-1）与眼表参数之间的相关性。30 名青春期前肥胖男孩和 30 名年龄和性别匹配的健康对照组男孩接受了体格测量、实验室测试和眼表评估。肥胖组的 IGF-1 水平较低（P = 0.001），Schirmer I 泪液测试（SIT）结果较差（P 结论：肥胖组的 IGF-1 水平较低（P = 0.001），SIT 结果较差（P = 0.001）：研究结果表明，肥胖青春期前男孩的 IGF-1 降低与 SIT 降低和 meiboscore 增加有独立联系，与肥胖和传统的心血管风险因素无关。这意味着，监测肥胖儿童的眼表参数可能会为临床实践提供一个新的关注视角：- 已知：肥胖儿童的 IGF-1 水平降低，而 IGF-1 的降低与肥胖引起的心血管代谢并发症有关。- 眼表组织可能是激素的靶点，可能会受到这些激素的局部影响：- 在青春期前肥胖的男孩中，IGF-1的减少与SIT的减少和meiboscore的增加有独立联系，与肥胖和传统的心血管风险因素无关。- 这一发现意味着，监测肥胖儿童的眼表参数可能会为临床实践提供一个新的关注视角。

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来源期刊

European Journal of Pediatrics 医学-小儿科

CiteScore

5.90

自引率

2.80%

发文量

367

审稿时长

3-6 weeks

期刊介绍： The European Journal of Pediatrics (EJPE) is a leading peer-reviewed medical journal which covers the entire field of pediatrics. The editors encourage authors to submit original articles, reviews, short communications, and correspondence on all relevant themes and topics. EJPE is particularly committed to the publication of articles on important new clinical research that will have an immediate impact on clinical pediatric practice. The editorial office very much welcomes ideas for publications, whether individual articles or article series, that fit this goal and is always willing to address inquiries from authors regarding potential submissions. Invited review articles on clinical pediatrics that provide comprehensive coverage of a subject of importance are also regularly commissioned. The short publication time reflects both the commitment of the editors and publishers and their passion for new developments in the field of pediatrics. EJPE is active on social media (@EurJPediatrics) and we invite you to participate. EJPE is the official journal of the European Academy of Paediatrics (EAP) and publishes guidelines and statements in cooperation with the EAP.