Current immunotherapy techniques in meningioma.

IF 2.9 3区 医学 Q2 ONCOLOGY Expert Review of Anticancer Therapy Pub Date : 2024-10-01 Epub Date: 2024-09-04 DOI:10.1080/14737140.2024.2399252
Alexandra J White, Maya Harary, Joshua Casaos, Richard G Everson
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Abstract

Introduction: Although meningiomas are the most common primary brain tumor, there are limited treatment options for recurrent or aggressive lesions. Compared to other brain tumors, meningiomas may be uniquely amenable to immunotherapy by virtue of their location outside the blood-brain barrier.

Areas covered: This review describes our current understanding of the immunology of the meninges, as well as immune cell infiltration and immune signaling in meningioma. Current literature on meningioma immunology and immunotherapy was comprehensively reviewed and summarized by a comprehensive search of MEDLINE (1/1/1990-6/1/2024). Further, we describe the current state of immunotherapeutic approaches, as well as potential future targets. Potential immunotherapeutic approaches include immune checkpoint inhibition, CAR-T approaches, tumor vaccine therapy, and immunogenic molecular markers.

Expert opinion: Meningioma immunotherapy is in early stages, as no immunotherapies are currently included in treatment guidelines. There is substantial heterogeneity in immune cell infiltration, immunogenicity, and immune escape across tumors, even within tumor grade. Furthering our understanding of meningioma immunology and tumor classification will allow for careful selection of tumors and patient populations that may benefit from primary or adjunctive immunotherapy for meningioma.

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脑膜瘤的现有免疫疗法技术。
简介:尽管脑膜瘤是最常见的原发性脑肿瘤,但针对复发或侵袭性病变的治疗方案却十分有限。与其他脑肿瘤相比,脑膜瘤由于位于血脑屏障之外,可能是唯一适合采用免疫疗法的肿瘤:本综述介绍了我们目前对脑膜免疫学以及脑膜瘤免疫细胞浸润和免疫信号转导的认识。通过对 MEDLINE(1/1/1990-6/1/2024)的全面检索,我们对当前有关脑膜瘤免疫学和免疫疗法的文献进行了全面回顾和总结。此外,我们还介绍了免疫治疗方法的现状以及未来的潜在靶点。潜在的免疫治疗方法包括免疫检查点抑制、CAR-T方法、肿瘤疫苗疗法和免疫原分子标记物:脑膜瘤免疫疗法尚处于早期阶段,因为目前还没有将免疫疗法纳入治疗指南。不同肿瘤的免疫细胞浸润、免疫原性和免疫逃逸存在很大的异质性,甚至在肿瘤分级中也是如此。我们对脑膜瘤免疫学和肿瘤分类的进一步了解将有助于仔细选择可能从脑膜瘤主要或辅助免疫疗法中获益的肿瘤和患者群体。
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来源期刊
CiteScore
5.10
自引率
3.00%
发文量
100
审稿时长
4-8 weeks
期刊介绍: Expert Review of Anticancer Therapy (ISSN 1473-7140) provides expert appraisal and commentary on the major trends in cancer care and highlights the performance of new therapeutic and diagnostic approaches. Coverage includes tumor management, novel medicines, anticancer agents and chemotherapy, biological therapy, cancer vaccines, therapeutic indications, biomarkers and diagnostics, and treatment guidelines. All articles are subject to rigorous peer-review, and the journal makes an essential contribution to decision-making in cancer care. Comprehensive coverage in each review is complemented by the unique Expert Review format and includes the following sections: Expert Opinion - a personal view of the data presented in the article, a discussion on the developments that are likely to be important in the future, and the avenues of research likely to become exciting as further studies yield more detailed results Article Highlights – an executive summary of the author’s most critical points.
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