Ectopic Production of Parathyroid Hormone and Production of Parathyroid Hormone-related Protein in Dedifferentiated Endometrial Carcinoma Induced Severe Hypercalcemia.

IF 1.1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL Internal Medicine Pub Date : 2025-04-01 Epub Date: 2024-09-04 DOI:10.2169/internalmedicine.3899-24

Takeru Ogino, Hirofumi Watanabe, Shoko Yamazaki, Megumi Kurosawa, Akiko Kobayashi, Naofumi Imai, Takahiro Taguchi, Hajime Umezu, Ryo Aida, Kazuki Watanabe, Tadashi Otsuka, Hideyuki Kabasawa, Ryohei Kaseda, Suguru Yamamoto, Kosuke Yoshihara, Shin Goto, Ichiei Narita

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Abstract

Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma. Postoperatively, PTH and PTHrP levels normalized but subsequently increased due to metastases. A molecular analysis confirmed the expression of the PTH gene and protein within the tumor, indicating ectopic PTH production. In diagnosing and treating cancers, it is necessary to consider not only PTHrP production but also ectopic PTH production.

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甲状旁腺激素的异位生成和甲状旁腺激素相关蛋白的生成在诱发严重高钙血症的未分化子宫内膜癌中的应用

高钙血症是癌症患者的一种重要并发症，主要由甲状旁腺激素相关肽（PTHrP）引起，很少由肿瘤产生的甲状旁腺激素（PTH）引起。我们报告了一例严重高钙血症病例，患者患有子宫癌，PTH 和 PTHrP 水平升高。手术治疗发现了已分化的子宫内膜癌。术后，PTH 和 PTHrP 水平恢复正常，但随后又因转移而升高。分子分析证实，肿瘤内存在 PTH 基因和蛋白的表达，表明存在异位 PTH 生成。在诊断和治疗癌症时，不仅要考虑 PTHrP 的产生，还要考虑异位 PTH 的产生。

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.