Effect of Topical Human Platelet Extract (HPE) for Facial Skin Rejuvenation: A Histological Study of Collagen and Elastin.

IF 1.5 4区医学 Q3 DERMATOLOGY Journal of Drugs in Dermatology Pub Date : 2024-09-01 DOI:10.36849/JDD.8162

Saranya P Wyles, Sydney L Proffer, Patricia Farris, Lindsey Randall, Matthew L Hillestad, Mary P Lupo, Atta Behfar

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Abstract

Background: Regenerative aesthetics has garnered significant attention. In this toolkit, exosomes are small extracellular vesicles derived from various sources such as platelets.

Objective: To characterize the cosmetic effect and tolerability of topical human platelet-derived extract (HPE), Intense Serum (Rion Aesthetics, Inc., Rochester, MN), on facial skin rejuvenation after 12 weeks of twice daily use without any confounding aesthetic procedures.

Materials and methods: This prospective, single-arm, non-randomized, evaluator-blinded clinical study evaluated subjects at baseline and 12 weeks using participant questionnaires and photo-documentation with Canfield VISIA-CR 3D PRIMOS. The histological evaluation included Masson's Trichrome for collagen and Verhoeff-Van Gieson staining for elastin. Electron microscopy characterized collagen bundle thickness.

Results: Fifty-six participants (mean age: 54 years old) were enrolled. Following topical HPE use, 87.3% of subjects reported improvement in facial skin aging including sustained pigment reduction and improvement in luminosity and color evenness at 12 weeks (P≤0.001). Histology revealed a significant increase in collagen fibril thickness at 12 weeks (P≤0.0001). No serious adverse effects.

Conclusion: This study demonstrates improvement in facial skin health after topical HPE use, supported by collagen and elastin formation in the dermis. The product is well-tolerated, and participants were satisfied with the overall cosmetic outcome. J Drugs Dermatol. 2024;23(9):735-740. doi:10.36849/JDD.8162.

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局部使用人血小板提取物（HPE）对面部皮肤年轻化的效果：胶原蛋白和弹性蛋白的组织学研究。

背景：再生美学备受关注。在这一工具包中，外泌体是从血小板等各种来源提取的小细胞外囊泡：目的：在不影响任何美容程序的情况下，研究外用人血小板衍生提取物（HPE）Intense Serum（Rion Aesthetics, Inc.，Rochester, MN）对面部皮肤年轻化的美容效果和耐受性：这项前瞻性、单臂、非随机、评估者盲法的临床研究使用坎菲尔德 VISIA-CR 3D PRIMOS 对受试者进行了基线和 12 周的评估，并进行了问卷调查和照片记录。组织学评估包括胶原蛋白的 Masson 三色染色和弹性蛋白的 Verhoeff-Van Gieson 染色。电子显微镜观察胶原束厚度：56 名参与者（平均年龄：54 岁）参加了评估。局部使用 HPE 后，87.3% 的受试者表示面部皮肤老化情况有所改善，包括 12 周后色素持续减少、光泽度和颜色均匀度有所改善（P≤0.001）。组织学检查显示，12 周后胶原纤维厚度明显增加（P≤0.0001）。无严重不良反应：这项研究表明，局部使用 HPE 后，面部皮肤健康状况有所改善，真皮层中胶原蛋白和弹性蛋白的形成为其提供了支持。该产品的耐受性良好，参与者对整体美容效果感到满意。J Drugs Dermatol.2024;23(9):735-740. doi:10.36849/JDD.8162.

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来源期刊

Journal of Drugs in Dermatology DERMATOLOGY-

CiteScore

2.20

自引率

13.30%

发文量

289

审稿时长

3-6 weeks

期刊介绍： The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.