Hepatic changes following a high-fat diet: effects of Cornus mas and gold nanoparticles phytoreduced with Cornus mas on oxidative stress, inflammation, and histological damage.

Q2 Medicine Medicine and Pharmacy Reports Pub Date : 2024-07-01 Epub Date: 2024-07-30 DOI:10.15386/mpr-2775
Dalina Diana Zugravu, Stefan Lucian Popa, Andrei-Vasile Pop, Remus Moldovan, Alexandru Flaviu Tăbăran, Luminita David, Simona Valeria Clichici
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Abstract

Background and aims: High fat diet (HFD) can lead to liver injury, through oxidative stress and inflammation. The use of natural compounds with antioxidant and anti-inflammatory properties can have a protective potential. We aimed to investigate the effects of Cornus mas (CM) and gold nanoparticles phytoreduced with CM (GNPsCM) on hepatic alterations induced by HFD in rats.

Methods: Female Sprague Dawley rats were randomly divided into four groups: control, HFD, HFD +CM and HFD + GNPsCM. The high fat diet was administered for 32 weeks and CM and GNPsCM were administered for 4 weeks after the HFD period. The high fat diet induced oxidative stress in liver, with lipid peroxidation and decreased antioxidant capacity, inflammation and minimal histological alterations.

Results: The administration of CM and GNPsCM reduced lipid peroxidation produced by HFD and increased antioxidant potential in liver homogenates, while increasing inflammatory markers. Histological alterations were slightly improved by the intervention of compounds, and hyaluronic acid content of the liver without statistical significance as compared to HFD group.

Conclusion: These findings support the potential of these treatments in addressing liver oxidative stress, mitigating liver damage induced by a high-fat diet. This investigation sheds light on the oxidative stress dynamics and histological alterations associated with high-fat diet-induced liver injury, contributing to our understanding of potential therapeutic interventions.

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高脂饮食后的肝脏变化:山茱萸和山茱萸植物还原金纳米粒子对氧化应激、炎症和组织学损伤的影响。
背景和目的:高脂饮食(HFD)可通过氧化应激和炎症导致肝损伤。使用具有抗氧化和抗炎特性的天然化合物可以起到保护作用。我们旨在研究山茱萸(CM)和用山茱萸还原的金纳米粒子(GNPsCM)对高密度脂蛋白膳食诱导的大鼠肝脏改变的影响:将雌性 Sprague Dawley 大鼠随机分为四组:对照组、HFD 组、HFD +CM 组和 HFD + GNPsCM 组。高脂饮食持续 32 周,在高脂饮食期后的 4 周内服用 CM 和 GNPsCM。高脂饮食会诱发肝脏氧化应激,导致脂质过氧化、抗氧化能力下降、炎症和最小组织学改变:结果:服用中药和 GNPsCM 可减少高脂饮食引起的脂质过氧化反应,提高肝脏匀浆中的抗氧化能力,同时增加炎症指标。与高频分解膳食组相比,这些化合物的干预略微改善了肝脏的组织学改变和透明质酸含量,但无统计学意义:这些发现支持了这些疗法在解决肝脏氧化应激、减轻高脂饮食引起的肝损伤方面的潜力。这项研究揭示了与高脂饮食诱导的肝损伤相关的氧化应激动态和组织学改变,有助于我们了解潜在的治疗干预措施。
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来源期刊
Medicine and Pharmacy Reports
Medicine and Pharmacy Reports Medicine-Medicine (all)
CiteScore
3.10
自引率
0.00%
发文量
63
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