Association between Secondhand Smoke Exposure and the Incidence of Stroke in Never Smoker According to Alcohol Intake: 19-Year Prospective Cohort Study in Korea.

Journal of occupational and environmental medicine Pub Date : 2024-12-01 Epub Date: 2024-09-04 DOI:10.1097/JOM.0000000000003225

Eujene Jung, Ho Goon Kim, Dong Ki Kim, Hyun Ho Ryu

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Abstract

Objectives: Our study aimed to investigate both the independent and combined effects of secondhand smoking (SHS) and alcohol intake on the occurrence of stroke.

Methods: Utilizing the Korean Genome Epidemiology Study prospective cohort data, our primary exposure variables were SHS exposure and alcohol intake. The occurrence of stroke served as the main outcome of interest. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression analysis. To assess the synergistic influence of SHS and alcohol intake on stroke incidence, a joint test was conducted.

Results: SHS exposure correlated with an HR of 1.53 (95% CI = 1.19 to 1.98) for stroke risk. The combined exposure to SHS and alcohol yielded an elevated stroke risk, with an HR of 1.75 (95% CI = 1.20 to 2.55).

Conclusions: Our research highlights the combined influence of SHS exposure and alcohol intake on stroke susceptibility.

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韩国为期 19 年的前瞻性队列研究：根据酒精摄入量确定从不吸烟者的二手烟暴露与中风发病率之间的关系。

研究目的我们的研究旨在调查二手烟（SHS）和酒精摄入对中风发生的独立影响和联合影响：方法：利用韩国基因组流行病学研究（KoGES）的前瞻性队列数据，我们的主要暴露变量是二手烟暴露和酒精摄入量。中风的发生是我们关注的主要结果。我们使用 Cox 回归分析法估算了危险比（HRs）和 95% 置信区间（CIs）。为评估 SHS 和酒精摄入对中风发病率的协同影响，进行了联合检验：结果：SHS 暴露与中风风险的 HR 值为 1.53（95% CI，1.19-1.98）。结果：接触 SHS 与中风风险的 HR 值为 1.53（95% CI，1.19-1.98），同时接触 SHS 和酒精会导致中风风险升高，HR 值为 1.75（95% CI，1.20-2.55）：我们的研究强调了暴露于 SHS 和摄入酒精对中风易感性的共同影响。

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Journal of occupational and environmental medicine

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