Caenorhabditis elegans for opioid addiction research

IF 4.8 2区 医学 Q1 NEUROSCIENCES Current Opinion in Neurobiology Pub Date : 2024-09-05 DOI:10.1016/j.conb.2024.102914
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Abstract

The problem of drug addiction has become a profound societal problem worldwide. A better understanding of the neurobiological basis of addiction and the discovery of more effective treatments are needed. Recent studies have shown that many mechanisms that underlie addiction exist in more primitive organisms, including the nematode Caenorhabditis elegans (C. elegans). C. elegans is also hypothesized to possess a functional opioid-like system, including the endogenous opioid-like peptide NLP-24 and opioid-like receptor NPR-17. Opioids, such as morphine, are thought to cause addiction-like behavior by activating dopamine nerves in C. elegans via the opioid-like system. Accumulating evidence suggests that C. elegans is an excellent animal model for identifying molecular mechanisms of addiction.

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用于阿片类药物成瘾研究的秀丽隐杆线虫
吸毒成瘾问题已成为全球范围内一个深刻的社会问题。我们需要更好地了解成瘾的神经生物学基础,并找到更有效的治疗方法。最近的研究表明,成瘾的许多机制存在于更原始的生物体中,包括线虫秀丽隐杆线虫(C. elegans)。据推测,优雅类线虫也拥有阿片样功能系统,包括内源性阿片样肽 NLP-24 和阿片样受体 NPR-17。类阿片(如吗啡)被认为是通过类阿片系统激活 elegans 中的多巴胺神经,从而导致类似上瘾的行为。越来越多的证据表明, elegans 是鉴定成瘾分子机制的绝佳动物模型。
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来源期刊
Current Opinion in Neurobiology
Current Opinion in Neurobiology 医学-神经科学
CiteScore
11.10
自引率
1.80%
发文量
130
审稿时长
4-8 weeks
期刊介绍: Current Opinion in Neurobiology publishes short annotated reviews by leading experts on recent developments in the field of neurobiology. These experts write short reviews describing recent discoveries in this field (in the past 2-5 years), as well as highlighting select individual papers of particular significance. The journal is thus an important resource allowing researchers and educators to quickly gain an overview and rich understanding of complex and current issues in the field of Neurobiology. The journal takes a unique and valuable approach in focusing each special issue around a topic of scientific and/or societal interest, and then bringing together leading international experts studying that topic, embracing diverse methodologies and perspectives. Journal Content: The journal consists of 6 issues per year, covering 8 recurring topics every other year in the following categories: -Neurobiology of Disease- Neurobiology of Behavior- Cellular Neuroscience- Systems Neuroscience- Developmental Neuroscience- Neurobiology of Learning and Plasticity- Molecular Neuroscience- Computational Neuroscience
期刊最新文献
Polygenicity in a box: Copy number variants, neural circuit development, and neurodevelopmental disorders The power of human stem cell-based systems in the study of neurodevelopmental disorders Epigenetics and the timing of neuronal differentiation Editorial Board Caenorhabditis elegans for opioid addiction research
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