A systems view of the vascular endothelium in health and disease

IF 45.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Cell Pub Date : 2024-09-05 DOI:10.1016/j.cell.2024.07.012
Hellmut G. Augustin, Gou Young Koh
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Abstract

The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality. Although endothelial cells, being present in all organs as a single-cell layer, are often conceived as a rather inert cell population, the vascular endothelium as a whole should be considered a highly dynamic and interactive systemically disseminated organ. We present here a holistic view of the field of vascular research and review the diverse functions of blood-vessel-lining endothelial cells during the life cycle of the vasculature, namely responsive and relaying functions of the vascular endothelium and the responsive roles as instructive gatekeepers of organ function. Emerging translational perspectives in regenerative medicine, preventive medicine, and aging research are developed. Collectively, this review is aimed at promoting disciplinary coherence in the field of angioscience for a broader appreciation of the importance of the vasculature for organ function, systemic health, and healthy aging.

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从系统角度看健康和疾病中的血管内皮
血管内皮细胞功能障碍是导致死亡的一个主要原因。虽然血管内皮细胞作为单细胞层存在于所有器官中,通常被认为是一个相当惰性的细胞群,但血管内皮细胞作为一个整体应被视为一个高度动态和互动的系统性分布器官。我们在此从整体上审视血管研究领域,回顾了血管内皮细胞在血管生命周期中的各种功能,即血管内皮细胞的响应和中继功能,以及作为器官功能指示守门员的响应作用。本综述提出了再生医学、预防医学和老龄化研究中新出现的转化观点。总之,本综述旨在促进血管科学领域的学科连贯性,使人们更广泛地认识到血管对器官功能、全身健康和健康老龄化的重要性。
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来源期刊
Cell
Cell 生物-生化与分子生物学
CiteScore
110.00
自引率
0.80%
发文量
396
审稿时长
2 months
期刊介绍: Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.
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