Human TCR repertoire in cancer

IF 2.9 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2024-09-06 DOI:10.1002/cam4.70164

Lin Chen, Yuan Hu, Bohao Zheng, Limei Luo, Zhenzhen Su

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Abstract

Background

T cells, the “superstar” of the immune system, play a crucial role in antitumor immunity. T-cell receptors (TCR) are crucial molecules that enable T cells to identify antigens and start immunological responses. The body has evolved a unique method for rearrangement, resulting in a vast diversity of TCR repertoires. A healthy TCR repertoire is essential for the particular identification of antigens by T cells.

Methods

In this article, we systematically summarized the TCR creation mechanisms and analysis methodologies, particularly focusing on the application of next-generation sequencing (NGS) technology. We explore the TCR repertoire in health and cancer, and discuss the implications of TCR repertoire analysis in understanding carcinogenesis, cancer progression, and treatment.

Results

The TCR repertoire analysis has enormous potential for monitoring the emergence and progression of malignancies, as well as assessing therapy response and prognosis. The application of NGS has dramatically accelerated our comprehension of TCR diversity and its role in cancer immunity.

Conclusions

To substantiate the significance of TCR repertoires as biomarkers, more thorough and exhaustive research should be conducted. The TCR repertoire analysis, enabled by advanced sequencing technologies, is poised to become a crucial tool in the future of cancer diagnosis, monitoring, and therapy evaluation.

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癌症中的人类 TCR 基因库。

背景：T 细胞是免疫系统中的 "超级明星"，在抗肿瘤免疫中发挥着至关重要的作用。T细胞受体（TCR）是使T细胞识别抗原并启动免疫反应的关键分子。人体进化出了一种独特的重排方法，从而形成了种类繁多的 TCR 基因库。健康的 TCR 重排对于 T 细胞识别抗原至关重要：在本文中，我们系统地总结了 TCR 的产生机制和分析方法，尤其关注下一代测序（NGS）技术的应用。我们探讨了健康和癌症中的 TCR 基因库，并讨论了 TCR 基因库分析对理解癌变、癌症进展和治疗的意义：结果：TCR 重排分析在监测恶性肿瘤的发生和发展以及评估治疗反应和预后方面具有巨大的潜力。NGS 的应用大大加快了我们对 TCR 多样性及其在癌症免疫中作用的理解：结论：要证实 TCR 重排作为生物标记物的重要性，应开展更深入、更详尽的研究。先进的测序技术使 TCR 重排分析成为未来癌症诊断、监测和治疗评估的重要工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.