Inflammatory bowel disease burden in the Middle East and North Africa Region: a comprehensive analysis of incidence, prevalence, and mortality from 1990-2019.

IF 2.1 Q3 GASTROENTEROLOGY & HEPATOLOGY Annals of Gastroenterology Pub Date : 2024-09-01 Epub Date: 2024-08-19 DOI:10.20524/aog.2024.0909
Saqr Alsakarneh, Mohamed Ahmed, Fouad Jaber, Mohammad Abuassi, Fadi H Mourad, Fadi F Francis, Kassem Barada, Rami Tfayli, Badr Al-Bawardy, Francis A Farraye, Jana G Hashash
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Abstract

Background: The epidemiology of inflammatory bowel disease (IBD) has changed rapidly in recent years. Objective data concerning the IBD burden in the Middle East and North Africa (MENA) region is limited. We aimed to provide a systematic report on the IBD burden in the MENA region. Additionally, we aimed to study the age- and sex-specific trends in IBD incidence, prevalence and mortality rates from 1990-2019.

Methods: Using the Global Burden of Disease (GBD) 2019 Study Database, we investigated the changes in incidence, prevalence and mortality rate, and disability-adjusted life-years (DALYs), at a regional and country level between 1990 and 2019.

Results: In 2019, there were 282,534 cases (95% confidence interval [CI] 239,506-334,478) of IBD in the MENA region (50.5% male). There was an overall increase in the incidence and prevalence rates of IBD in the MENA region from 1990 to 2019, while a simultaneous decrease in overall mortality rates was identified. Incidence rates were highest in Jordan, at 6.9 (95%CI 5.8-8.1) per 100,000, and lowest in Morocco, at 1.6 (95%CI 1.4-2) per 100,000. From 1990-2019, the incidence was found increased in males at a higher rate than in females. The age-standardized mortality rate decreased for both sexes by 24% from 1990-2019.

Conclusion: The trends and geographic variations in IBD within the MENA region provide policymakers with vital information for making informed decisions in policy, research, and investment, thereby enabling the development of more effective strategies and better allocation of resources.

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中东和北非地区的炎症性肠病负担:1990-2019 年发病率、流行率和死亡率综合分析。
背景:近年来,炎症性肠病 (IBD) 的流行病学发生了迅速变化。有关中东和北非地区 IBD 负担的客观数据非常有限。我们旨在提供一份关于中东和北非地区 IBD 负担的系统报告。此外,我们还旨在研究 1990-2019 年间特定年龄和性别的 IBD 发病率、流行率和死亡率趋势:利用全球疾病负担(GBD)2019 年研究数据库,我们调查了 1990 年至 2019 年期间地区和国家层面的发病率、流行率和死亡率以及残疾调整生命年(DALYs)的变化情况:2019年,中东和北非地区共有282,534例(95%置信区间[CI] 239,506-334,478)IBD病例(50.5%为男性)。从 1990 年到 2019 年,中东和北非地区的 IBD 发病率和流行率总体呈上升趋势,而总死亡率则同步下降。约旦的发病率最高,为每 10 万人 6.9 例(95%CI 5.8-8.1 例),摩洛哥的发病率最低,为每 10 万人 1.6 例(95%CI 1.4-2 例)。1990-2019 年间,男性发病率的增长速度高于女性。1990-2019年期间,男女的年龄标准化死亡率均下降了24%:中东和北非地区 IBD 的发展趋势和地域差异为政策制定者在政策、研究和投资方面做出明智决策提供了重要信息,从而有助于制定更有效的战略和更好地分配资源。
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来源期刊
Annals of Gastroenterology
Annals of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.30
自引率
0.00%
发文量
58
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